TKTL1 [The Human Chemical-Genetic Interaction Map Project]

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======= TKTL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TKTL1
  * **<color #00a2e8>Official Name</color>**: transketolase like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8277|8277]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51854|P51854]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TKTL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TKTL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300044|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transket pyr|
|E1 dh|
|Transketolase C|
|Transketolase N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transketolase activity|
|thiamine metabolic process|
|thiamine-containing compound metabolic process|
|glucose catabolic process|
|hexose catabolic process|
|monosaccharide catabolic process|
|water-soluble vitamin metabolic process|
|pyrimidine-containing compound metabolic process|
|glucose metabolic process|
|carbohydrate catabolic process|
|vitamin metabolic process|
|hexose metabolic process|
|monosaccharide metabolic process|
|sulfur compound metabolic process|
|small molecule catabolic process|
|carbohydrate metabolic process|
|drug metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-3.06|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.06|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.05|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.02|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.86|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.74|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.71|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pnkp|PNKP]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17764
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TKTL1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>