TLN1 [The Human Chemical-Genetic Interaction Map Project]

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======= TLN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TLN1
  * **<color #00a2e8>Official Name</color>**: talin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7094|7094]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y490|Q9Y490]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TLN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TLN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186745|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I LWEQ|
|Talin middle|
|VBS|
|FERM M|
|FERM N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|LIM domain binding|
|integrin activation|
|cytoskeletal anchoring at plasma membrane|
|vinculin binding|
|cortical actin cytoskeleton organization|
|cell-substrate junction assembly|
|platelet aggregation|
|cortical cytoskeleton organization|
|IRE1-mediated unfolded protein response|
|homotypic cell-cell adhesion|
|phosphatidylserine binding|
|maintenance of protein location in cell|
|phosphatidylinositol binding|
|ruffle|
|integrin-mediated signaling pathway|
|maintenance of location in cell|
|ruffle membrane|
|structural constituent of cytoskeleton|
|cell-cell junction assembly|
|endoplasmic reticulum unfolded protein response|
|maintenance of protein location|
|cellular response to unfolded protein|
|platelet degranulation|
|integrin binding|
|cell-cell junction organization|
|platelet activation|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|maintenance of location|
|cell junction assembly|
|response to topologically incorrect protein|
|actin filament binding|
|cell junction organization|
|muscle contraction|
|response to endoplasmic reticulum stress|
|blood coagulation|
|coagulation|
|hemostasis|
|muscle system process|
|cadherin binding|
|cytoskeleton|
|focal adhesion|
|wound healing|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|cell-cell adhesion|
|actin filament-based process|
|response to wounding|
|cell surface|
|viral process|
|regulated exocytosis|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|cell adhesion|
|biological adhesion|
|secretion by cell|
|export from cell|
|cell activation|
|cytoskeleton organization|
|secretion|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|cellular response to stress|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 304/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|5/28|
|bone|11/26|
|breast|13/33|
|central nervous system|25/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|11/21|
|liver|9/20|
|lung|30/75|
|lymphocyte|1/16|
|ovary|16/26|
|pancreas|16/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|17/24|
|soft tissue|6/9|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|8/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13317
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TLN1 Expression in NALM6 Cells: 8.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>