TLR8 [The Human Chemical-Genetic Interaction Map Project]

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======= TLR8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TLR8
  * **<color #00a2e8>Official Name</color>**: toll like receptor 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51311|51311]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR97|Q9NR97]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TLR8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TLR8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300366|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:23520111}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|toll-like receptor 8 signaling pathway|
|negative regulation of interleukin-12 secretion|
|positive regulation of interferon-alpha biosynthetic process|
|regulation of interferon-alpha biosynthetic process|
|positive regulation of interferon-beta biosynthetic process|
|regulation of interferon-beta biosynthetic process|
|regulation of interleukin-12 secretion|
|signaling pattern recognition receptor activity|
|positive regulation of interleukin-8 biosynthetic process|
|positive regulation of interferon-gamma biosynthetic process|
|endolysosome membrane|
|toll-like receptor 9 signaling pathway|
|regulation of interleukin-8 biosynthetic process|
|negative regulation of interleukin-12 production|
|regulation of interferon-gamma biosynthetic process|
|positive regulation of interferon-alpha production|
|regulation of interferon-alpha production|
|leukocyte activation involved in inflammatory response|
|microglial cell activation|
|positive regulation of interferon-beta production|
|positive regulation of interleukin-6 secretion|
|MyD88-dependent toll-like receptor signaling pathway|
|positive regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 secretion|
|glial cell activation|
|neuroinflammatory response|
|regulation of interleukin-1 beta secretion|
|single-stranded RNA binding|
|regulation of interferon-beta production|
|positive regulation of interleukin-8 production|
|macrophage activation|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-1 secretion|
|regulation of interleukin-12 production|
|drug binding|
|positive regulation of interleukin-1 production|
|positive regulation of interferon-gamma production|
|positive regulation of cytokine biosynthetic process|
|negative regulation of cytokine secretion|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of interleukin-8 production|
|double-stranded RNA binding|
|positive regulation of type I interferon production|
|cellular response to mechanical stimulus|
|regulation of interleukin-1 beta production|
|regulation of interleukin-1 production|
|positive regulation of interleukin-6 production|
|toll-like receptor signaling pathway|
|regulation of interferon-gamma production|
|regulation of cytokine biosynthetic process|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|negative regulation of protein secretion|
|transmembrane signaling receptor activity|
|positive regulation of cytokine secretion|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|defense response to virus|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|signaling receptor activity|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|endosome membrane|
|response to mechanical stimulus|
|negative regulation of secretion|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|lymphocyte mediated immunity|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to virus|
|positive regulation of peptide secretion|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|cellular response to external stimulus|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|external side of plasma membrane|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|adaptive immune response|
|Golgi membrane|
|activation of immune response|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|regulation of secretion|
|positive regulation of immune response|
|leukocyte activation|
|endoplasmic reticulum membrane|
|defense response to other organism|
|positive regulation of transport|
|regulation of protein localization|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|regulation of protein phosphorylation|
|DNA binding|
|regulation of response to stress|
|regulation of phosphorylation|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15341
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TLR8 Expression in NALM6 Cells: -2.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>