TLR9 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= TLR9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TLR9
  * **<color #00a2e8>Official Name</color>**: toll like receptor 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54106|54106]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR96|Q9NR96]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TLR9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TLR9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605474|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endolysosome|
|unmethylated CpG binding|
|positive regulation of interferon-alpha biosynthetic process|
|negative regulation of ATPase-coupled calcium transmembrane transporter activity|
|positive regulation of interleukin-18 production|
|regulation of interferon-alpha biosynthetic process|
|positive regulation of interferon-beta biosynthetic process|
|tumor necrosis factor production|
|regulation of interleukin-18 production|
|regulation of interferon-beta biosynthetic process|
|regulation of toll-like receptor 9 signaling pathway|
|tumor necrosis factor superfamily cytokine production|
|regulation of ATPase-coupled calcium transmembrane transporter activity|
|signaling pattern recognition receptor activity|
|siRNA binding|
|early phagosome|
|positive regulation of interleukin-8 biosynthetic process|
|I-kappaB phosphorylation|
|positive regulation of granulocyte macrophage colony-stimulating factor production|
|positive regulation of interferon-gamma biosynthetic process|
|endolysosome membrane|
|interleukin-1 receptor binding|
|positive regulation of nitric-oxide synthase biosynthetic process|
|regulation of granulocyte macrophage colony-stimulating factor production|
|regulation of interleukin-8 biosynthetic process|
|toll-like receptor 9 signaling pathway|
|regulation of interferon-gamma biosynthetic process|
|negative regulation of interleukin-8 production|
|regulation of nitric-oxide synthase biosynthetic process|
|maintenance of gastrointestinal epithelium|
|positive regulation of toll-like receptor signaling pathway|
|positive regulation of interferon-alpha production|
|epithelial structure maintenance|
|regulation of B cell differentiation|
|regulation of interferon-alpha production|
|positive regulation of interferon-beta production|
|MyD88-dependent toll-like receptor signaling pathway|
|negative regulation of calcium ion transmembrane transporter activity|
|positive regulation of interleukin-12 production|
|positive regulation of interleukin-10 production|
|negative regulation of calcium ion transmembrane transport|
|negative regulation of toll-like receptor signaling pathway|
|positive regulation of B cell proliferation|
|positive regulation of immunoglobulin production|
|negative regulation of interleukin-6 production|
|regulation of interferon-beta production|
|positive regulation of interleukin-8 production|
|regulation of interleukin-10 production|
|regulation of interleukin-12 production|
|positive regulation of chemokine production|
|negative regulation of calcium ion transport|
|regulation of B cell proliferation|
|positive regulation of interferon-gamma production|
|regulation of immunoglobulin production|
|positive regulation of cytokine biosynthetic process|
|regulation of toll-like receptor signaling pathway|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of interleukin-8 production|
|negative regulation of ion transmembrane transporter activity|
|positive regulation of JUN kinase activity|
|digestive system process|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of chemokine production|
|positive regulation of type I interferon production|
|negative regulation of transporter activity|
|negative regulation of NF-kappaB transcription factor activity|
|negative regulation of cation transmembrane transport|
|defense response to Gram-negative bacterium|
|positive regulation of tumor necrosis factor production|
|regulation of JUN kinase activity|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of calcium ion transmembrane transporter activity|
|positive regulation of interleukin-6 production|
|negative regulation of ion transmembrane transport|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|toll-like receptor signaling pathway|
|regulation of cytokine biosynthetic process|
|regulation of NIK/NF-kappaB signaling|
|digestion|
|negative regulation of transmembrane transport|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|transmembrane signaling receptor activity|
|positive regulation of inflammatory response|
|positive regulation of JNK cascade|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|regulation of tumor necrosis factor production|
|cytokine production|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|negative regulation of DNA-binding transcription factor activity|
|positive regulation of B cell activation|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of lymphocyte differentiation|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|tissue homeostasis|
|defense response to virus|
|basolateral plasma membrane|
|regulation of cytokine secretion|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|endosome membrane|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|regulation of stress-activated MAPK cascade|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of calcium ion transport|
|lysosome|
|activation of innate immune response|
|regulation of ion transmembrane transporter activity|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|regulation of transmembrane transporter activity|
|endosome|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|regulation of transporter activity|
|response to virus|
|apical plasma membrane|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|defense response to bacterium|
|regulation of cation transmembrane transport|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|regulation of metal ion transport|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|Golgi membrane|
|activation of immune response|
|regulation of cell activation|
|positive regulation of transferase activity|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of secretion|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|endoplasmic reticulum membrane|
|defense response to other organism|
|protein phosphorylation|
|regulation of transferase activity|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7900
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TLR9 Expression in NALM6 Cells: 3.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>