TM2D1 [The Human Chemical-Genetic Interaction Map Project]

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======= TM2D1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TM2D1
  * **<color #00a2e8>Official Name</color>**: TM2 domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83941|83941]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BX74|Q9BX74]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TM2D1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TM2D1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610080|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42. {ECO:0000269|PubMed:11278849, ECO:0000269|PubMed:12836168}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TM2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|amyloid-beta binding|
|apoptotic signaling pathway|
|G protein-coupled receptor activity|
|apoptotic process|
|programmed cell death|
|cell death|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.38|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.89|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.71|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.8|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.81|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.86|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.88|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.89|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.95|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.96|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.03|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tm2d2|TM2D2]]|0.423|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10448
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TM2D1 Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>