TM2D2 [The Human Chemical-Genetic Interaction Map Project]

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======= TM2D2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TM2D2
  * **<color #00a2e8>Official Name</color>**: TM2 domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83877|83877]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BX73|Q9BX73]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TM2D2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TM2D2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610081|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TM2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-4.86|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.38|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.1|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.04|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.02|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.97|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.78|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.76|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.72|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.7|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.75|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.85|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.23|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.75|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tm2d3|TM2D3]]|0.538|
|[[:human genes:t:tm2d1|TM2D1]]|0.423|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16241
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TM2D2 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>