TMEM106B [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM106B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM106B
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 106B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54664|54664]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NUM4|Q9NUM4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM106B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM106B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613413|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching. {ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:24357581}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1356|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysosome localization|
|dendrite morphogenesis|
|lysosome organization|
|lytic vacuole organization|
|positive regulation of dendrite development|
|dendrite development|
|lysosomal transport|
|late endosome membrane|
|vacuole organization|
|vacuolar transport|
|regulation of dendrite development|
|lysosome|
|endosome|
|positive regulation of neuron projection development|
|lysosomal membrane|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell morphogenesis involved in differentiation|
|organelle localization|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|molecular function|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.97|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.92|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.91|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.7|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|2.02|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.7|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.91|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15737
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM106B Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>