TMEM173 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM173 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STING1
  * **<color #00a2e8>Official Name</color>**: stimulator of interferon response cGAMP interactor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=340061|340061]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86WV6|Q86WV6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM173&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM173|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612374|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263). {ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:19776740, ECO:0000269|PubMed:21074459, ECO:0000269|PubMed:21947006, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:23258412, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722158, ECO:0000269|PubMed:26229117, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:26669264}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclic-di-GMP binding|
|integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane|
|cyclic-GMP-AMP binding|
|interferon-beta production|
|reticulophagy|
|cytoplasmic pattern recognition receptor signaling pathway in response to virus|
|type I interferon production|
|cellular response to exogenous dsRNA|
|cellular response to dsRNA|
|multi-organism cellular process|
|selective autophagy|
|positive regulation of defense response to virus by host|
|cellular response to virus|
|autophagosome membrane|
|cytoplasmic pattern recognition receptor signaling pathway|
|regulation of defense response to virus by host|
|response to exogenous dsRNA|
|response to dsRNA|
|autophagosome assembly|
|organelle disassembly|
|autophagosome organization|
|positive regulation of macroautophagy|
|autophagosome|
|regulation of defense response to virus|
|positive regulation of type I interferon production|
|positive regulation of protein binding|
|secretory granule membrane|
|positive regulation of autophagy|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|vacuole organization|
|cytoplasmic vesicle membrane|
|cytokine production|
|macroautophagy|
|mitochondrial outer membrane|
|intracellular receptor signaling pathway|
|regulation of macroautophagy|
|positive regulation of binding|
|defense response to virus|
|regulation of protein binding|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|process utilizing autophagic mechanism|
|autophagy|
|positive regulation of DNA-binding transcription factor activity|
|endosome|
|response to virus|
|regulation of autophagy|
|transcription factor binding|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|positive regulation of cellular catabolic process|
|regulation of binding|
|cellular component disassembly|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|protein kinase binding|
|regulation of immune effector process|
|positive regulation of defense response|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|cellular response to organic cyclic compound|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|cellular response to nitrogen compound|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|viral process|
|regulated exocytosis|
|organelle assembly|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|protein homodimerization activity|
|response to organic cyclic compound|
|leukocyte activation|
|endoplasmic reticulum membrane|
|defense response to other organism|
|regulation of catabolic process|
|secretion by cell|
|export from cell|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of transcription by RNA polymerase II|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|cellular catabolic process|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-2.09|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.81|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.8|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14748
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM173 Expression in NALM6 Cells: 2.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>