TMEM189 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM189 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM189
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 189
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=387521|387521]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A5PLL7|A5PLL7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM189&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM189|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kua-UEV1 localn|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-3.49|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-3.32|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.97|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.71|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.45|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.35|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.3|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.13|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.11|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.04|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.04|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.99|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.83|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.82|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.78|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.77|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.71|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.7|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.77|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.82|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.88|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|3.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:ept1|EPT1]]|0.549|
|[[:human genes:a:agps|AGPS]]|0.451|
|[[:human genes:f:far1|FAR1]]|0.44|
|[[:human genes:p:pex1|PEX1]]|0.435|
|[[:human genes:p:pcyt2|PCYT2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4829
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM189 Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>