TMEM199 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM199 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM199
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 199
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=147007|147007]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N511|Q8N511]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM199&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM199|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) in some human cells. The encoded protein shares some homology with the yeast protein Vma12. Defects in this gene are a cause of congenital disorder of glycosylation, type IIp. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833330). {ECO:0000269|PubMed:26833330, ECO:0000269|PubMed:28296633}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vma12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysosomal protein catabolic process|
|protein catabolic process in the vacuole|
|COPI-coated vesicle membrane|
|vacuolar proton-transporting V-type ATPase complex assembly|
|proton-transporting V-type ATPase complex assembly|
|lysosomal lumen acidification|
|regulation of lysosomal lumen pH|
|proton-transporting two-sector ATPase complex assembly|
|cellular response to increased oxygen levels|
|vacuolar proton-transporting V-type ATPase complex|
|vacuolar acidification|
|response to increased oxygen levels|
|intracellular pH reduction|
|pH reduction|
|lysosome organization|
|lytic vacuole organization|
|cellular iron ion homeostasis|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|iron ion homeostasis|
|regulation of intracellular pH|
|regulation of cellular pH|
|regulation of pH|
|cellular transition metal ion homeostasis|
|cellular monovalent inorganic cation homeostasis|
|vacuole organization|
|transition metal ion homeostasis|
|monovalent inorganic cation homeostasis|
|cellular response to oxygen levels|
|lysosome|
|response to oxygen levels|
|cellular metal ion homeostasis|
|cellular protein catabolic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|protein catabolic process|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular protein-containing complex assembly|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chemical homeostasis|
|response to abiotic stimulus|
|protein-containing complex assembly|
|homeostatic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.11|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.9|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.88|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.84|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.541|
|[[:human genes:r:rrp7a|RRP7A]]|0.417|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.416|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 267/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|15/28|
|bone|14/26|
|breast|15/33|
|central nervous system|11/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|6/21|
|liver|4/20|
|lung|20/75|
|lymphocyte|5/16|
|ovary|7/26|
|pancreas|6/24|
|peripheral nervous system|3/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|12/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 625
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM199 Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>