TMEM208 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM208 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM208
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 208
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29100|29100]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BTX3|Q9BTX3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM208&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM208|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620781|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. {ECO:0000269|PubMed:23691174}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF788|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vacuolar protein processing|
|vacuole|
|protein processing|
|protein maturation|
|process utilizing autophagic mechanism|
|autophagy|
|endoplasmic reticulum membrane|
|proteolysis|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.65|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.25|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.23|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.19|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.03|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.95|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.9|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.86|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.83|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.83|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.79|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.76|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.76|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.76|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.74|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.7|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.7|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.83|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.95|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.99|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.02|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.29|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.56|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.62|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.63|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.74|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.91|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.36|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.66|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|5.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cmtr2|CMTR2]]|0.435|
|[[:human genes:r:rpe|RPE]]|0.418|
|[[:human genes:a:atic|ATIC]]|0.416|
|[[:human genes:s:slc20a1|SLC20A1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8343
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM208 Expression in NALM6 Cells: 4.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>