TMEM41B [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM41B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM41B
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 41B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=440026|440026]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5BJD5|Q5BJD5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM41B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM41B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620271|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal motor neuron development. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE assoc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|autophagosome assembly|
|autophagosome organization|
|vacuole organization|
|macroautophagy|
|autophagy|
|process utilizing autophagic mechanism|
|organelle assembly|
|endoplasmic reticulum membrane|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.98|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.89|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.8|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.79|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.72|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.71|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.72|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.73|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.89|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.9|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.92|
|[[:results:exp539|42°C R08 exp539]]|2.02|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.16|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.31|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rptor|RPTOR]]|0.592|
|[[:human genes:d:dpagt1|DPAGT1]]|0.584|
|[[:human genes:a:alg1|ALG1]]|0.554|
|[[:human genes:t:triap1|TRIAP1]]|0.542|
|[[:human genes:p:pmm2|PMM2]]|0.541|
|[[:human genes:g:gfpt1|GFPT1]]|0.527|
|[[:human genes:u:uap1|UAP1]]|0.527|
|[[:human genes:c:cbfb|CBFB]]|0.525|
|[[:human genes:t:thg1l|THG1L]]|0.525|
|[[:human genes:p:pelo|PELO]]|0.52|
|[[:human genes:t:tmed10|TMED10]]|0.509|
|[[:human genes:v:vmp1|VMP1]]|0.508|
|[[:human genes:r:rnmt|RNMT]]|0.508|
|[[:human genes:a:alg5|ALG5]]|0.505|
|[[:human genes:d:dnajc3|DNAJC3]]|0.505|
|[[:human genes:m:mllt1|MLLT1]]|0.504|
|[[:human genes:h:hspd1|HSPD1]]|0.504|
|[[:human genes:e:eif4e|EIF4E]]|0.503|
|[[:human genes:e:eef1e1|EEF1E1]]|0.501|
|[[:human genes:t:trmt10a|TRMT10A]]|0.496|
|[[:human genes:u:uhrf1|UHRF1]]|0.493|
|[[:human genes:c:ccdc101|CCDC101]]|0.493|
|[[:human genes:r:rpe|RPE]]|0.493|
|[[:human genes:m:med16|MED16]]|0.491|
|[[:human genes:w:wdr24|WDR24]]|0.491|
|[[:human genes:g:gmppb|GMPPB]]|0.49|
|[[:human genes:w:wdr59|WDR59]]|0.489|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.487|
|[[:human genes:r:rtcb|RTCB]]|0.484|
|[[:human genes:u:ube2j1|UBE2J1]]|0.477|
|[[:human genes:t:taz|TAZ]]|0.477|
|[[:human genes:d:dohh|DOHH]]|0.476|
|[[:human genes:a:atxn10|ATXN10]]|0.475|
|[[:human genes:r:rad1|RAD1]]|0.471|
|[[:human genes:o:otud5|OTUD5]]|0.471|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.464|
|[[:human genes:a:atp5a1|ATP5A1]]|0.463|
|[[:human genes:l:lsm11|LSM11]]|0.461|
|[[:human genes:m:mtor|MTOR]]|0.461|
|[[:human genes:a:atp5b|ATP5B]]|0.46|
|[[:human genes:m:med23|MED23]]|0.46|
|[[:human genes:g:gnb1l|GNB1L]]|0.457|
|[[:human genes:t:tti1|TTI1]]|0.456|
|[[:human genes:t:trmt5|TRMT5]]|0.455|
|[[:human genes:e:eif1ax|EIF1AX]]|0.455|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.454|
|[[:human genes:p:polr3h|POLR3H]]|0.451|
|[[:human genes:r:rpp21|RPP21]]|0.451|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.45|
|[[:human genes:p:pam16|PAM16]]|0.45|
|[[:human genes:x:xpo6|XPO6]]|0.449|
|[[:human genes:u:ube2g2|UBE2G2]]|0.448|
|[[:human genes:d:dpf2|DPF2]]|0.446|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.446|
|[[:human genes:m:meaf6|MEAF6]]|0.444|
|[[:human genes:r:romo1|ROMO1]]|0.444|
|[[:human genes:e:eny2|ENY2]]|0.444|
|[[:human genes:h:hars|HARS]]|0.444|
|[[:human genes:i:id3|ID3]]|0.443|
|[[:human genes:p:ppcs|PPCS]]|0.442|
|[[:human genes:a:atp5j|ATP5J]]|0.442|
|[[:human genes:o:oraov1|ORAOV1]]|0.441|
|[[:human genes:t:timm13|TIMM13]]|0.44|
|[[:human genes:s:srp14|SRP14]]|0.44|
|[[:human genes:l:lsm10|LSM10]]|0.44|
|[[:human genes:t:trnt1|TRNT1]]|0.439|
|[[:human genes:a:alg2|ALG2]]|0.439|
|[[:human genes:n:nae1|NAE1]]|0.439|
|[[:human genes:c:cbx3|CBX3]]|0.438|
|[[:human genes:a:alg13|ALG13]]|0.437|
|[[:human genes:m:mapk14|MAPK14]]|0.435|
|[[:human genes:h:hccs|HCCS]]|0.434|
|[[:human genes:a:atp5o|ATP5O]]|0.433|
|[[:human genes:a:alg6|ALG6]]|0.432|
|[[:human genes:m:mad2l1|MAD2L1]]|0.43|
|[[:human genes:d:dhps|DHPS]]|0.43|
|[[:human genes:e:eif3f|EIF3F]]|0.43|
|[[:human genes:a:aars|AARS]]|0.429|
|[[:human genes:m:mbtps2|MBTPS2]]|0.427|
|[[:human genes:e:exoc4|EXOC4]]|0.427|
|[[:human genes:c:crls1|CRLS1]]|0.427|
|[[:human genes:w:wars|WARS]]|0.425|
|[[:human genes:b:bub3|BUB3]]|0.425|
|[[:human genes:v:vezt|VEZT]]|0.422|
|[[:human genes:t:thoc6|THOC6]]|0.421|
|[[:human genes:z:zrsr2|ZRSR2]]|0.42|
|[[:human genes:t:tti2|TTI2]]|0.419|
|[[:human genes:d:dhdds|DHDDS]]|0.419|
|[[:human genes:n:nsd1|NSD1]]|0.419|
|[[:human genes:p:pdap1|PDAP1]]|0.418|
|[[:human genes:e:eno1|ENO1]]|0.417|
|[[:human genes:l:lsmd1|LSMD1]]|0.416|
|[[:human genes:a:atf7ip|ATF7IP]]|0.415|
|[[:human genes:u:utp23|UTP23]]|0.415|
|[[:human genes:s:sec62|SEC62]]|0.412|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.411|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.411|
|[[:human genes:s:sdha|SDHA]]|0.41|
|[[:human genes:b:bap1|BAP1]]|0.41|
|[[:human genes:f:fh|FH]]|0.409|
|[[:human genes:s:slc25a26|SLC25A26]]|0.409|
|[[:human genes:s:ssb|SSB]]|0.408|
|[[:human genes:m:med4|MED4]]|0.407|
|[[:human genes:n:nars|NARS]]|0.407|
|[[:human genes:s:srp68|SRP68]]|0.406|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.406|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.406|
|[[:human genes:a:adsl|ADSL]]|0.405|
|[[:human genes:o:osgep|OSGEP]]|0.405|
|[[:human genes:p:ppa2|PPA2]]|0.405|
|[[:human genes:a:atp5d|ATP5D]]|0.404|
|[[:human genes:p:pggt1b|PGGT1B]]|0.404|
|[[:human genes:m:manf|MANF]]|0.403|
|[[:human genes:e:elac2|ELAC2]]|0.402|
|[[:human genes:d:dhrsx|DHRSX]]|0.402|
|[[:human genes:p:plaa|PLAA]]|0.401|
|[[:human genes:d:derl2|DERL2]]|0.401|
|[[:human genes:t:tle4|TLE4]]|0.4|
|[[:human genes:t:txnrd1|TXNRD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5068
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM41B Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>