TMEM63C [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM63C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM63C
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 63C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57156|57156]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P1W3|Q9P1W3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM63C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM63C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619953|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an osmosensitive calcium-permeable cation channel. {ECO:0000269|PubMed:24503647}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF221|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium activated cation channel activity|
|cation transport|
|ion transmembrane transport|
|transmembrane transport|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.7|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.7|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.74|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.77|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.08|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.42|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15214
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM63C Expression in NALM6 Cells: 4.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>