TMSB4X [The Human Chemical-Genetic Interaction Map Project]

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======= TMSB4X =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMSB4X
  * **<color #00a2e8>Official Name</color>**: thymosin beta 4 X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7114|7114]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62328|P62328]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMSB4X&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMSB4X|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300159|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thymosin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of proton-transporting ATP synthase activity, rotational mechanism|
|regulation of proton-transporting ATP synthase activity, rotational mechanism|
|negative regulation of interleukin-8 secretion|
|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|cytoplasmic sequestering of NF-kappaB|
|sequestering of actin monomers|
|positive regulation of ATP biosynthetic process|
|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|positive regulation of endothelial cell chemotaxis|
|cytoplasmic sequestering of transcription factor|
|regulation of ATP biosynthetic process|
|negative regulation of interleukin-8 production|
|negative regulation of transcription regulatory region DNA binding|
|regulation of endothelial cell chemotaxis|
|regulation of proton transport|
|negative regulation of NIK/NF-kappaB signaling|
|positive regulation of nucleotide biosynthetic process|
|positive regulation of purine nucleotide biosynthetic process|
|cytoplasmic sequestering of protein|
|regulation of interleukin-8 secretion|
|actin monomer binding|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|positive regulation of ATP metabolic process|
|positive regulation of nucleotide metabolic process|
|positive regulation of purine nucleotide metabolic process|
|regulation of transcription regulatory region DNA binding|
|negative regulation of actin filament polymerization|
|positive regulation of blood vessel endothelial cell migration|
|negative regulation of DNA binding|
|negative regulation of protein polymerization|
|platelet alpha granule lumen|
|negative regulation of cytokine secretion|
|regulation of interleukin-8 production|
|maintenance of protein location in cell|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of blood vessel endothelial cell migration|
|maintenance of location in cell|
|positive regulation of endothelial cell migration|
|positive regulation of ion transmembrane transporter activity|
|maintenance of protein location|
|regulation of NIK/NF-kappaB signaling|
|positive regulation of transporter activity|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|tumor necrosis factor-mediated signaling pathway|
|regulation of ATP metabolic process|
|regulation of DNA binding|
|platelet degranulation|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|negative regulation of protein secretion|
|positive regulation of chemotaxis|
|positive regulation of small molecule metabolic process|
|negative regulation of cytoskeleton organization|
|negative regulation of peptide secretion|
|positive regulation of epithelial cell migration|
|positive regulation of cation transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of endothelial cell migration|
|negative regulation of DNA-binding transcription factor activity|
|maintenance of location|
|regulation of actin filament polymerization|
|negative regulation of binding|
|negative regulation of protein transport|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|negative regulation of establishment of protein localization|
|positive regulation of transmembrane transport|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of chemotaxis|
|regulation of epithelial cell migration|
|regulation of protein polymerization|
|negative regulation of secretion|
|actin filament organization|
|cellular response to tumor necrosis factor|
|regulation of ion transmembrane transporter activity|
|regulation of actin filament organization|
|response to tumor necrosis factor|
|regulation of transmembrane transporter activity|
|negative regulation of cytokine production|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of cation transmembrane transport|
|regulation of inflammatory response|
|regulation of actin cytoskeleton organization|
|enzyme binding|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|negative regulation of organelle organization|
|regulation of binding|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of small molecule metabolic process|
|regulation of DNA-binding transcription factor activity|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|regulation of protein secretion|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|regulation of transmembrane transport|
|actin filament-based process|
|positive regulation of response to external stimulus|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of ion transport|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|exocytosis|
|regulation of secretion|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|RNA binding|
|regulation of response to stress|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.22|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.73|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16189
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMSB4X Expression in NALM6 Cells: 9.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>