TNFAIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TNFAIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFAIP1
  * **<color #00a2e8>Official Name</color>**: TNF alpha induced protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7126|7126]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13829|Q13829]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFAIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFAIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191161|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000269|PubMed:19637314, ECO:0000269|PubMed:19782033}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|K tetra|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|stress fiber assembly|
|contractile actin filament bundle assembly|
|GTP-Rho binding|
|negative regulation of Rho protein signal transduction|
|positive regulation of DNA replication|
|Cul3-RING ubiquitin ligase complex|
|negative regulation of Ras protein signal transduction|
|negative regulation of small GTPase mediated signal transduction|
|actin filament bundle assembly|
|actin filament bundle organization|
|regulation of DNA replication|
|actomyosin structure organization|
|regulation of Rho protein signal transduction|
|DNA replication|
|actin filament organization|
|regulation of Ras protein signal transduction|
|protein domain specific binding|
|ubiquitin-protein transferase activity|
|endosome|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|protein homooligomerization|
|regulation of small GTPase mediated signal transduction|
|proteasomal protein catabolic process|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|negative regulation of intracellular signal transduction|
|protein complex oligomerization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|actin filament-based process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|nucleolus|
|cellular macromolecule catabolic process|
|apoptotic process|
|cell migration|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell motility|
|localization of cell|
|cell death|
|cytoskeleton organization|
|negative regulation of signal transduction|
|proteolysis|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4699
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFAIP1 Expression in NALM6 Cells: 4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>