TNFRSF10D [The Human Chemical-Genetic Interaction Map Project]

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======= TNFRSF10D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFRSF10D
  * **<color #00a2e8>Official Name</color>**: TNF receptor superfamily member 10d
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8793|8793]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBN6|Q9UBN6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFRSF10D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFRSF10D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603614|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNFR c6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAIL binding|
|transmembrane signaling receptor activity|
|leukocyte migration|
|cell surface|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|cell migration|
|negative regulation of cell death|
|programmed cell death|
|cell motility|
|localization of cell|
|cell death|
|locomotion|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-2.03|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.96|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.96|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.92|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.87|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.85|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.84|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.75|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.71|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.74|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.77|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.78|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18410
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFRSF10D Expression in NALM6 Cells: 3.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>