TNFSF4 [The Human Chemical-Genetic Interaction Map Project]

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======= TNFSF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFSF4
  * **<color #00a2e8>Official Name</color>**: TNF superfamily member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7292|7292]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23510|P23510]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFSF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFSF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603594|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to nitrogen dioxide|
|regulation of interleukin-4-dependent isotype switching to IgE isotypes|
|positive regulation of CD4-positive, alpha-beta T cell costimulation|
|chemokine (C-C motif) ligand 11 production|
|T-helper 2 cell activation|
|positive regulation of interleukin-4-dependent isotype switching to IgE isotypes|
|positive regulation of T cell costimulation|
|memory T cell activation|
|defense response to nematode|
|regulation of CD4-positive, alpha-beta T cell costimulation|
|negative regulation of T-helper 1 cell differentiation|
|regulation of T cell costimulation|
|positive regulation of isotype switching to IgE isotypes|
|tumor necrosis factor receptor superfamily binding|
|negative regulation of regulatory T cell differentiation|
|regulation of isotype switching to IgE isotypes|
|positive regulation of memory T cell differentiation|
|negative regulation of T-helper 1 type immune response|
|positive regulation of T-helper 2 cell differentiation|
|chemokine production|
|regulation of memory T cell differentiation|
|regulation of T-helper 1 cell differentiation|
|regulation of T-helper 2 cell differentiation|
|positive regulation of immunoglobulin secretion|
|negative regulation of interleukin-17 production|
|positive regulation of interleukin-13 production|
|negative regulation of T-helper cell differentiation|
|positive regulation of type 2 immune response|
|cellular response to prostaglandin E stimulus|
|positive regulation of T cell cytokine production|
|regulation of immunoglobulin secretion|
|positive regulation of alpha-beta T cell proliferation|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of T-helper cell differentiation|
|cellular response to prostaglandin stimulus|
|regulation of interleukin-13 production|
|response to prostaglandin E|
|positive regulation of interleukin-4 production|
|negative regulation of alpha-beta T cell differentiation|
|positive regulation of isotype switching|
|regulation of T-helper 1 type immune response|
|regulation of interleukin-4 production|
|regulation of interleukin-17 production|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of regulatory T cell differentiation|
|regulation of type 2 immune response|
|regulation of alpha-beta T cell proliferation|
|response to prostaglandin|
|tumor necrosis factor receptor binding|
|regulation of T cell cytokine production|
|negative regulation of interferon-gamma production|
|regulation of isotype switching|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|regulation of T-helper cell differentiation|
|positive regulation of interleukin-12 production|
|positive regulation of interleukin-10 production|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|negative regulation of alpha-beta T cell activation|
|positive regulation of DNA recombination|
|CD4-positive, alpha-beta T cell activation|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of immunoglobulin production|
|negative regulation of T cell differentiation|
|negative regulation of adaptive immune response|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of T cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|regulation of interleukin-10 production|
|negative regulation of lymphocyte differentiation|
|positive regulation of cytokine production involved in immune response|
|regulation of interleukin-12 production|
|cellular response to fatty acid|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|regulation of immunoglobulin production|
|positive regulation of interferon-gamma production|
|regulation of T cell mediated immunity|
|acute inflammatory response|
|positive regulation of T cell differentiation|
|regulation of cytokine production involved in immune response|
|cellular response to alcohol|
|response to fatty acid|
|cellular response to ketone|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of interleukin-6 production|
|positive regulation of T cell proliferation|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of leukocyte differentiation|
|regulation of DNA recombination|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|negative regulation of T cell activation|
|tumor necrosis factor-mediated signaling pathway|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|negative regulation of hemopoiesis|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|regulation of T cell proliferation|
|negative regulation of DNA-binding transcription factor activity|
|regulation of adaptive immune response|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|cytokine activity|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|cellular response to molecule of bacterial origin|
|positive regulation of DNA metabolic process|
|response to ketone|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|cellular response to acid chemical|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|response to alcohol|
|T cell activation|
|cellular response to tumor necrosis factor|
|positive regulation of cell-cell adhesion|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|response to virus|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|signaling receptor binding|
|regulation of inflammatory response|
|response to acid chemical|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of peptide secretion|
|inflammatory response|
|regulation of lymphocyte activation|
|cellular response to lipid|
|response to inorganic substance|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|cell surface|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|response to lipid|
|positive regulation of immune response|
|response to hormone|
|positive regulation of cell population proliferation|
|leukocyte activation|
|negative regulation of developmental process|
|defense response to other organism|
|positive regulation of cell differentiation|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.82|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16359
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFSF4 Expression in NALM6 Cells: 1.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>