TNIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TNIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNIP1
  * **<color #00a2e8>Official Name</color>**: TNFAIP3 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10318|10318]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15025|Q15025]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607714|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|
|modulation by symbiont of host signal transduction pathway|
|modulation of signal transduction in other organism involved in symbiotic interaction|
|modulation of signal transduction in other organism|
|positive regulation of protein deubiquitination|
|regulation of protein deubiquitination|
|mitogen-activated protein kinase binding|
|modulation by symbiont of host cellular process|
|polyubiquitin modification-dependent protein binding|
|MyD88-dependent toll-like receptor signaling pathway|
|modification by symbiont of host morphology or physiology|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|leukocyte cell-cell adhesion|
|negative regulation of viral genome replication|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of viral life cycle|
|regulation of viral genome replication|
|negative regulation of viral process|
|toll-like receptor signaling pathway|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|pattern recognition receptor signaling pathway|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of inflammatory response|
|regulation of viral life cycle|
|modification of morphology or physiology of other organism|
|interaction with host|
|negative regulation of MAPK cascade|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of protein modification by small protein conjugation or removal|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|activation of innate immune response|
|protein deubiquitination|
|regulation of ERK1 and ERK2 cascade|
|protein modification by small protein removal|
|glycoprotein biosynthetic process|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|positive regulation of proteolysis|
|positive regulation of response to biotic stimulus|
|translation|
|glycoprotein metabolic process|
|negative regulation of protein phosphorylation|
|peptide biosynthetic process|
|negative regulation of phosphorylation|
|regulation of innate immune response|
|positive regulation of defense response|
|inflammatory response|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|amide biosynthetic process|
|peptide metabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|carbohydrate derivative biosynthetic process|
|activation of immune response|
|regulation of proteolysis|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|positive regulation of immune response|
|cell adhesion|
|biological adhesion|
|protein modification by small protein conjugation or removal|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.94|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.76|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12120
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNIP1 Expression in NALM6 Cells: 4.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>