TNNI3K [The Human Chemical-Genetic Interaction Map Project]

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======= TNNI3K =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNNI3K
  * **<color #00a2e8>Official Name</color>**: TNNI3 interacting kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51086|51086]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q59H18|Q59H18]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNNI3K&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNNI3K|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613932|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in cardiac physiology. {ECO:0000303|PubMed:12721663}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Ank|
|Ank 2|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|troponin I binding|
|bundle of His cell to Purkinje myocyte communication|
|cell communication involved in cardiac conduction|
|regulation of cardiac conduction|
|regulation of cardiac muscle contraction|
|regulation of striated muscle contraction|
|cardiac conduction|
|regulation of heart rate|
|multicellular organismal signaling|
|regulation of muscle contraction|
|protein C-terminus binding|
|regulation of muscle system process|
|protein kinase activity|
|regulation of heart contraction|
|regulation of blood circulation|
|protein serine/threonine kinase activity|
|regulation of system process|
|protein phosphorylation|
|phosphorylation|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.77|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16258
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNNI3K Expression in NALM6 Cells: 2.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>