TNNT1 [The Human Chemical-Genetic Interaction Map Project]

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======= TNNT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNNT1
  * **<color #00a2e8>Official Name</color>**: troponin T1, slow skeletal type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7138|7138]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13805|P13805]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNNT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNNT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191041|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Troponin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|slow-twitch skeletal muscle fiber contraction|
|calcium-dependent ATPase activity|
|twitch skeletal muscle contraction|
|voluntary skeletal muscle contraction|
|troponin T binding|
|transition between fast and slow fiber|
|troponin complex|
|tropomyosin binding|
|regulation of skeletal muscle adaptation|
|negative regulation of muscle contraction|
|skeletal muscle contraction|
|muscle filament sliding|
|actin-myosin filament sliding|
|multicellular organismal movement|
|musculoskeletal movement|
|sarcomere organization|
|myofibril assembly|
|cardiac muscle contraction|
|regulation of muscle adaptation|
|heart contraction|
|actin-mediated cell contraction|
|heart process|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|striated muscle cell development|
|muscle cell development|
|regulation of muscle contraction|
|striated muscle cell differentiation|
|regulation of muscle system process|
|muscle cell differentiation|
|muscle contraction|
|muscle system process|
|blood circulation|
|circulatory system process|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|actin filament-based process|
|regulation of system process|
|calcium ion binding|
|organelle assembly|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|cytoskeleton organization|
|negative regulation of multicellular organismal process|
|movement of cell or subcellular component|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.91|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4788
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.66 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNNT1 Expression in NALM6 Cells: -1.66'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>