TNNT2 [The Human Chemical-Genetic Interaction Map Project]

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======= TNNT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNNT2
  * **<color #00a2e8>Official Name</color>**: troponin T2, cardiac type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7139|7139]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P45379|P45379]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNNT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNNT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191045|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Troponin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|troponin C binding|
|cardiac Troponin complex|
|calcium-dependent ATPase activity|
|troponin I binding|
|cardiac myofibril|
|troponin complex|
|tropomyosin binding|
|negative regulation of ATPase activity|
|striated muscle thin filament|
|skeletal muscle contraction|
|actin-myosin filament sliding|
|muscle filament sliding|
|musculoskeletal movement|
|multicellular organismal movement|
|sarcomere organization|
|ventricular cardiac muscle tissue morphogenesis|
|sarcomere|
|positive regulation of ATPase activity|
|ventricular cardiac muscle tissue development|
|myofibril assembly|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|cardiac muscle contraction|
|muscle tissue morphogenesis|
|regulation of ATPase activity|
|heart contraction|
|muscle organ morphogenesis|
|actin-mediated cell contraction|
|heart process|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|striated muscle cell development|
|muscle cell development|
|response to calcium ion|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cardiac chamber development|
|striated muscle cell differentiation|
|regulation of muscle system process|
|regulation of heart contraction|
|muscle cell differentiation|
|heart morphogenesis|
|muscle contraction|
|actin binding|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|response to metal ion|
|blood circulation|
|circulatory system process|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|heart development|
|response to inorganic substance|
|tissue morphogenesis|
|actin filament-based process|
|regulation of system process|
|calcium ion binding|
|organelle assembly|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|cellular component morphogenesis|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|cytoskeleton organization|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|cell development|
|tissue development|
|positive regulation of molecular function|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.566|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|2/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3529
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNNT2 Expression in NALM6 Cells: 1.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>