TOM1L2 [The Human Chemical-Genetic Interaction Map Project]

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======= TOM1L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOM1L2
  * **<color #00a2e8>Official Name</color>**: target of myb1 like 2 membrane trafficking protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=146691|146691]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZVM7|Q6ZVM7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOM1L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOM1L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615519|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable role in protein transport. May regulate growth factor-induced mitogenic signaling. {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VHS|
|GAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|clathrin binding|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|cell|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|negative regulation of organelle organization|
|protein kinase binding|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|intracellular protein transport|
|regulation of cell cycle|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.02|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.7|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.77|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12200
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOM1L2 Expression in NALM6 Cells: 3.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>