TOMM6 [The Human Chemical-Genetic Interaction Map Project]

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======= TOMM6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOMM6
  * **<color #00a2e8>Official Name</color>**: translocase of outer mitochondrial membrane 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100188893|100188893]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96B49|Q96B49]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOMM6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOMM6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616168|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial outer membrane translocase complex|
|macroautophagy|
|mitochondrial outer membrane|
|process utilizing autophagic mechanism|
|autophagy|
|mitochondrion|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|cellular catabolic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gtpbp10|GTPBP10]]|0.508|
|[[:human genes:g:gfm2|GFM2]]|0.493|
|[[:human genes:m:mrpl21|MRPL21]]|0.492|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.484|
|[[:human genes:c:c12orf65|C12orf65]]|0.478|
|[[:human genes:m:mrps34|MRPS34]]|0.474|
|[[:human genes:r:rpusd4|RPUSD4]]|0.468|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.459|
|[[:human genes:n:ndufa3|NDUFA3]]|0.453|
|[[:human genes:l:lars2|LARS2]]|0.453|
|[[:human genes:n:ndufa2|NDUFA2]]|0.45|
|[[:human genes:n:ndufs2|NDUFS2]]|0.449|
|[[:human genes:s:ssbp1|SSBP1]]|0.448|
|[[:human genes:n:ndufb11|NDUFB11]]|0.448|
|[[:human genes:r:rpusd3|RPUSD3]]|0.447|
|[[:human genes:g:gfm1|GFM1]]|0.446|
|[[:human genes:m:mtg2|MTG2]]|0.444|
|[[:human genes:r:rbfa|RBFA]]|0.444|
|[[:human genes:m:mrps21|MRPS21]]|0.444|
|[[:human genes:p:pars2|PARS2]]|0.443|
|[[:human genes:s:selrc1|SELRC1]]|0.441|
|[[:human genes:a:aars2|AARS2]]|0.44|
|[[:human genes:m:mrps16|MRPS16]]|0.436|
|[[:human genes:p:polg2|POLG2]]|0.436|
|[[:human genes:m:mtg1|MTG1]]|0.435|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.428|
|[[:human genes:f:ftsj2|FTSJ2]]|0.428|
|[[:human genes:m:mrpl47|MRPL47]]|0.426|
|[[:human genes:e:ears2|EARS2]]|0.425|
|[[:human genes:t:tomm20|TOMM20]]|0.424|
|[[:human genes:s:slc25a26|SLC25A26]]|0.418|
|[[:human genes:s:sco2|SCO2]]|0.417|
|[[:human genes:m:mrps6|MRPS6]]|0.417|
|[[:human genes:d:dap3|DAP3]]|0.416|
|[[:human genes:m:mrpl45|MRPL45]]|0.415|
|[[:human genes:q:qrsl1|QRSL1]]|0.412|
|[[:human genes:g:gatc|GATC]]|0.412|
|[[:human genes:m:mrps23|MRPS23]]|0.412|
|[[:human genes:v:vars2|VARS2]]|0.412|
|[[:human genes:b:bcs1l|BCS1L]]|0.41|
|[[:human genes:m:mrpl23|MRPL23]]|0.41|
|[[:human genes:t:tars2|TARS2]]|0.41|
|[[:human genes:m:mrps26|MRPS26]]|0.409|
|[[:human genes:p:pet117|PET117]]|0.409|
|[[:human genes:m:mrps25|MRPS25]]|0.408|
|[[:human genes:n:ndufa1|NDUFA1]]|0.406|
|[[:human genes:m:mrpl53|MRPL53]]|0.405|
|[[:human genes:w:wars2|WARS2]]|0.404|
|[[:human genes:d:dnlz|DNLZ]]|0.403|
|[[:human genes:n:nars2|NARS2]]|0.402|
|[[:human genes:m:mrps24|MRPS24]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6758
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOMM6 Expression in NALM6 Cells: 4.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>