TOMM70A [The Human Chemical-Genetic Interaction Map Project]

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======= TOMM70A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOMM70
  * **<color #00a2e8>Official Name</color>**: translocase of outer mitochondrial membrane 70
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9868|9868]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94826|O94826]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOMM70A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOMM70A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606081|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor that accelerates the import of all mitochondrial precursor proteins. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 1|
|TPR 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial outer membrane translocase complex|
|protein transmembrane transporter activity|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|macroautophagy|
|mitochondrial outer membrane|
|mitochondrial transport|
|autophagy|
|process utilizing autophagic mechanism|
|protein targeting|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|intracellular protein transport|
|mitochondrion|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.08|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.02|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.87|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.82|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.8|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.77|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.89|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mtch2|MTCH2]]|0.464|
|[[:human genes:n:nsun4|NSUN4]]|0.43|
|[[:human genes:a:ankrd49|ANKRD49]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1098
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOMM70A Expression in NALM6 Cells: 7.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>