TOMM7 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= TOMM7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOMM7
  * **<color #00a2e8>Official Name</color>**: translocase of outer mitochondrial membrane 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54543|54543]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0U1|Q9P0U1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOMM7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOMM7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria. {ECO:0000269|PubMed:18331822, ECO:0000269|PubMed:24270810}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tom7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitophagy in response to mitochondrial depolarization|
|positive regulation of mitophagy|
|mitochondrial outer membrane translocase complex|
|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|regulation of mitophagy|
|response to mitochondrial depolarisation|
|protein import into mitochondrial matrix|
|positive regulation of autophagy of mitochondrion|
|protein transmembrane transporter activity|
|positive regulation of protein targeting to mitochondrion|
|protein transmembrane import into intracellular organelle|
|regulation of autophagy of mitochondrion|
|regulation of protein targeting to mitochondrion|
|intracellular protein transmembrane transport|
|protein targeting to mitochondrion|
|positive regulation of establishment of protein localization to mitochondrion|
|protein transmembrane transport|
|positive regulation of macroautophagy|
|establishment of protein localization to mitochondrion|
|regulation of establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|regulation of protein targeting|
|mitochondrial transmembrane transport|
|positive regulation of mitochondrion organization|
|positive regulation of autophagy|
|protein import|
|positive regulation of intracellular protein transport|
|macroautophagy|
|mitochondrial outer membrane|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|positive regulation of intracellular transport|
|mitochondrial transport|
|regulation of intracellular protein transport|
|autophagy|
|process utilizing autophagic mechanism|
|regulation of protein stability|
|positive regulation of cellular protein localization|
|regulation of autophagy|
|regulation of intracellular transport|
|protein targeting|
|positive regulation of cellular catabolic process|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|establishment of protein localization to organelle|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular catabolic process|
|regulation of cellular localization|
|positive regulation of transport|
|intracellular protein transport|
|regulation of catabolic process|
|regulation of protein localization|
|positive regulation of cellular component organization|
|mitochondrion|
|transmembrane transport|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.1|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.72|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.76|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.84|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.84|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.85|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.93|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.96|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.16|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.31|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lars2|LARS2]]|0.494|
|[[:human genes:g:gfm1|GFM1]]|0.473|
|[[:human genes:n:ndufs5|NDUFS5]]|0.466|
|[[:human genes:r:rmnd1|RMND1]]|0.45|
|[[:human genes:m:mrps21|MRPS21]]|0.448|
|[[:human genes:n:nars2|NARS2]]|0.447|
|[[:human genes:m:mrp63|MRP63]]|0.445|
|[[:human genes:f:ftsj2|FTSJ2]]|0.443|
|[[:human genes:f:fastkd2|FASTKD2]]|0.441|
|[[:human genes:v:vars2|VARS2]]|0.434|
|[[:human genes:n:ndufa11|NDUFA11]]|0.424|
|[[:human genes:m:mrps6|MRPS6]]|0.423|
|[[:human genes:p:pnpt1|PNPT1]]|0.423|
|[[:human genes:m:mars2|MARS2]]|0.42|
|[[:human genes:m:mrpl21|MRPL21]]|0.419|
|[[:human genes:e:eral1|ERAL1]]|0.416|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.412|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.41|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.41|
|[[:human genes:n:ndufa3|NDUFA3]]|0.41|
|[[:human genes:d:dap3|DAP3]]|0.406|
|[[:human genes:t:tfb1m|TFB1M]]|0.405|
|[[:human genes:r:rpusd4|RPUSD4]]|0.402|
|[[:human genes:t:trit1|TRIT1]]|0.401|
|[[:human genes:m:mrpl20|MRPL20]]|0.4|
|[[:human genes:m:mrps23|MRPS23]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4923
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOMM7 Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>