TP53RK [The Human Chemical-Genetic Interaction Map Project]

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======= TP53RK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TP53RK
  * **<color #00a2e8>Official Name</color>**: TP53 regulating kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=112858|112858]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96S44|Q96S44]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TP53RK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TP53RK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608679|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. {ECO:0000250, ECO:0000269|PubMed:11546806}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RIO1|
|Kdo|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|EKC/KEOPS complex|
|tRNA threonylcarbamoyladenosine metabolic process|
|p53 binding|
|hydrolase activity|
|tRNA processing|
|regulation of signal transduction by p53 class mediator|
|tRNA metabolic process|
|protein serine/threonine kinase activity|
|ncRNA processing|
|ncRNA metabolic process|
|RNA processing|
|protein phosphorylation|
|phosphorylation|
|ATP binding|
|RNA metabolic process|
|regulation of intracellular signal transduction|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.16|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.15|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.08|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.9|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.87|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.84|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.82|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.8|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.77|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.77|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.76|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.72|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.72|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rtcb|RTCB]]|0.426|
|[[:human genes:g:gnb1l|GNB1L]]|0.42|
|[[:human genes:o:osgep|OSGEP]]|0.408|
|[[:human genes:a:actr10|ACTR10]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 80/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|6/28|
|bone|4/26|
|breast|3/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|3/21|
|liver|4/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|1/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 751
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TP53RK Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>