TP63 [The Human Chemical-Genetic Interaction Map Project]

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======= TP63 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TP63
  * **<color #00a2e8>Official Name</color>**: tumor protein p63
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8626|8626]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3D4|Q9H3D4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TP63&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TP63|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603273|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P53 tetramer|
|P53|
|SAM 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ectoderm and mesoderm interaction|
|epidermal cell division|
|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|
|positive regulation of somatic stem cell population maintenance|
|regulation of epidermal cell division|
|cloacal septation|
|female genitalia morphogenesis|
|prostatic bud formation|
|cloaca development|
|replicative cell aging|
|regulation of somatic stem cell population maintenance|
|morphogenesis of an epithelial bud|
|negative regulation of keratinocyte differentiation|
|MDM2/MDM4 family protein binding|
|positive regulation of fibroblast apoptotic process|
|negative regulation of mesoderm development|
|skin morphogenesis|
|positive regulation of stem cell population maintenance|
|lateral sprouting from an epithelium|
|prostate glandular acinus development|
|positive regulation of keratinocyte proliferation|
|epithelial cell differentiation involved in prostate gland development|
|genitalia morphogenesis|
|negative regulation of intracellular estrogen receptor signaling pathway|
|negative regulation of epidermal cell differentiation|
|regulation of fibroblast apoptotic process|
|female genitalia development|
|regulation of mesoderm development|
|negative regulation of epidermis development|
|morphogenesis of an epithelial fold|
|post-anal tail morphogenesis|
|polarized epithelial cell differentiation|
|sympathetic nervous system development|
|prostate gland epithelium morphogenesis|
|establishment of skin barrier|
|establishment of planar polarity|
|establishment of tissue polarity|
|prostate gland morphogenesis|
|hair follicle morphogenesis|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of water loss via skin|
|embryonic hindlimb morphogenesis|
|regulation of stem cell population maintenance|
|epidermis morphogenesis|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|proximal/distal pattern formation|
|WW domain binding|
|regulation of keratinocyte proliferation|
|embryonic forelimb morphogenesis|
|animal organ formation|
|multicellular organism aging|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|hindlimb morphogenesis|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|glandular epithelial cell differentiation|
|negative regulation of epithelial cell differentiation|
|forelimb morphogenesis|
|prostate gland development|
|regulation of keratinocyte differentiation|
|regulation of intracellular estrogen receptor signaling pathway|
|morphogenesis of a polarized epithelium|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|neuron apoptotic process|
|autonomic nervous system development|
|genitalia development|
|digestive tract morphogenesis|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|neuron death|
|positive regulation of Notch signaling pathway|
|damaged DNA binding|
|positive regulation of osteoblast differentiation|
|positive regulation of establishment of protein localization to mitochondrion|
|rough endoplasmic reticulum|
|regulation of epidermal cell differentiation|
|cell aging|
|cranial skeletal system development|
|p53 binding|
|multicellular organismal water homeostasis|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of mitochondrial membrane permeability|
|hair follicle development|
|regulation of establishment of protein localization to mitochondrion|
|skin epidermis development|
|water homeostasis|
|hair cycle process|
|molting cycle process|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of membrane permeability|
|odontogenesis of dentin-containing tooth|
|positive regulation of ossification|
|regulation of epidermis development|
|hair cycle|
|molting cycle|
|protein homotetramerization|
|columnar/cuboidal epithelial cell differentiation|
|gland morphogenesis|
|regulation of Notch signaling pathway|
|double-stranded DNA binding|
|female sex differentiation|
|regulation of osteoblast differentiation|
|positive regulation of mitochondrion organization|
|signal transduction by p53 class mediator|
|odontogenesis|
|positive regulation of protein localization to membrane|
|mesoderm development|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|Notch signaling pathway|
|mitochondrial membrane organization|
|digestive tract development|
|regulation of epithelial cell differentiation|
|digestive system development|
|morphogenesis of embryonic epithelium|
|intrinsic apoptotic signaling pathway|
|limb morphogenesis|
|appendage morphogenesis|
|protein tetramerization|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|chromatin remodeling|
|regulation of cell division|
|morphogenesis of a branching structure|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|regulation of signal transduction by p53 class mediator|
|limb development|
|appendage development|
|positive regulation of epithelial cell proliferation|
|regulation of protein localization to membrane|
|regulation of ossification|
|epithelial cell development|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitochondrial transport|
|transcription regulatory region DNA binding|
|nuclear chromatin|
|regulation of cysteine-type endopeptidase activity|
|sex differentiation|
|keratinocyte differentiation|
|aging|
|apoptotic signaling pathway|
|epidermal cell differentiation|
|urogenital system development|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|regionalization|
|regulation of epithelial cell proliferation|
|protein homooligomerization|
|skin development|
|chromatin binding|
|regulation of apoptotic signaling pathway|
|gland development|
|epidermis development|
|regulation of endopeptidase activity|
|sequence-specific DNA binding|
|dendrite|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|pattern specification process|
|mitochondrion organization|
|regulation of peptidase activity|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of establishment of protein localization|
|cell division|
|skeletal system development|
|regulation of body fluid levels|
|protein complex oligomerization|
|regulation of cellular protein localization|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|tissue morphogenesis|
|embryonic morphogenesis|
|protein-containing complex|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|gamete generation|
|positive regulation of cell death|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of establishment of protein localization|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|membrane organization|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|apoptotic process|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|Golgi apparatus|
|positive regulation of transport|
|multi-organism reproductive process|
|regulation of protein localization|
|programmed cell death|
|chromosome organization|
|identical protein binding|
|cell death|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 16/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12803
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TP63 Expression in NALM6 Cells: -0.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>