TPBG [The Human Chemical-Genetic Interaction Map Project]

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======= TPBG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TPBG
  * **<color #00a2e8>Official Name</color>**: trophoblast glycoprotein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7162|7162]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13641|Q13641]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TPBG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TPBG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190920|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a- dependent LRP6 internalization. {ECO:0000269|PubMed:22100263}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRRNT|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of synapse assembly|
|regulation of synapse assembly|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|cell surface|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|endoplasmic reticulum|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.76|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.78|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.79|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.83|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.85|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.86|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.1|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.16|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3545
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TPBG Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>