TPP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TPP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TPP1
  * **<color #00a2e8>Official Name</color>**: tripeptidyl peptidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1200|1200]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14773|O14773]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TPP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TPP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607998|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). {ECO:0000250|UniProtKB:Q9EQV6}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase S8|
|Pro-kuma activ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tripeptidyl-peptidase activity|
|bone resorption|
|peptide catabolic process|
|bone remodeling|
|peptide binding|
|neuromuscular process controlling balance|
|IRE1-mediated unfolded protein response|
|lytic vacuole organization|
|serine-type peptidase activity|
|lysosome organization|
|endopeptidase activity|
|peptidase activity|
|lysosomal lumen|
|tissue remodeling|
|melanosome|
|endoplasmic reticulum unfolded protein response|
|neuromuscular process|
|cellular response to unfolded protein|
|vacuole organization|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|serine-type endopeptidase activity|
|response to topologically incorrect protein|
|tissue homeostasis|
|lysosome|
|response to endoplasmic reticulum stress|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|peptide metabolic process|
|epithelial cell differentiation|
|protein catabolic process|
|cellular amide metabolic process|
|central nervous system development|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|epithelium development|
|lipid metabolic process|
|proteolysis|
|nervous system process|
|homeostatic process|
|cellular response to stress|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13153
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TPP1 Expression in NALM6 Cells: 7.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>