TPT1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= TPT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TPT1
  * **<color #00a2e8>Official Name</color>**: tumor protein, translationally-controlled 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7178|7178]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13693|P13693]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TPT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TPT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600763|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in calcium binding and microtubule stabilization.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TCTP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|multivesicular body|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|cytoplasmic microtubule|
|negative regulation of response to DNA damage stimulus|
|negative regulation of intrinsic apoptotic signaling pathway|
|spindle pole|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|calcium ion transport|
|response to virus|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of apoptotic signaling pathway|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|negative regulation of intracellular signal transduction|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|chemical homeostasis|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|RNA binding|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of cell death|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.47|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.19|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.98|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.97|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.74|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.75|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.82|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.95|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.27|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.68|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|4.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dph6|DPH6]]|0.428|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 210/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|10/28|
|bone|9/26|
|breast|8/33|
|central nervous system|16/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|9/21|
|liver|9/20|
|lung|20/75|
|lymphocyte|3/16|
|ovary|6/26|
|pancreas|6/24|
|peripheral nervous system|4/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|5/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1223
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TPT1 Expression in NALM6 Cells: 9.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>