TRA2B [The Human Chemical-Genetic Interaction Map Project]

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======= TRA2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRA2B
  * **<color #00a2e8>Official Name</color>**: transformer 2 beta homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6434|6434]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62995|P62995]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRA2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRA2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602719|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebral cortex regionalization|
|embryonic brain development|
|telencephalon regionalization|
|pre-mRNA binding|
|positive regulation of mRNA splicing, via spliceosome|
|forebrain regionalization|
|positive regulation of mRNA processing|
|positive regulation of RNA splicing|
|nuclear inner membrane|
|regulation of alternative mRNA splicing, via spliceosome|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|positive regulation of mRNA metabolic process|
|cellular response to carbohydrate stimulus|
|cellular glucose homeostasis|
|spliceosomal complex|
|regulation of mRNA splicing, via spliceosome|
|cerebral cortex development|
|regulation of RNA splicing|
|response to glucose|
|regulation of mRNA processing|
|response to hexose|
|response to monosaccharide|
|ribonucleoprotein complex|
|mRNA binding|
|response to carbohydrate|
|pallium development|
|glucose homeostasis|
|carbohydrate homeostasis|
|protein domain specific binding|
|telencephalon development|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|regionalization|
|forebrain development|
|RNA splicing|
|embryonic organ development|
|pattern specification process|
|mRNA processing|
|protein complex oligomerization|
|mRNA metabolic process|
|brain development|
|cellular chemical homeostasis|
|head development|
|RNA processing|
|cellular homeostasis|
|embryo development|
|central nervous system development|
|cellular response to oxygen-containing compound|
|identical protein binding|
|chemical homeostasis|
|RNA binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.7|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.71|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.72|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.76|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.76|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.77|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.84|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.9|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.18|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.467|
|[[:human genes:s:smg7|SMG7]]|0.449|
|[[:human genes:s:stil|STIL]]|0.443|
|[[:human genes:k:kremen1|KREMEN1]]|0.441|
|[[:human genes:p:psmd1|PSMD1]]|0.43|
|[[:human genes:p:psmd11|PSMD11]]|0.426|
|[[:human genes:c:cwc22|CWC22]]|0.425|
|[[:human genes:s:smg1|SMG1]]|0.424|
|[[:human genes:z:zfand5|ZFAND5]]|0.414|
|[[:human genes:c:cox8a|COX8A]]|0.409|
|[[:human genes:w:wdr87|WDR87]]|0.409|
|[[:human genes:m:myt1l|MYT1L]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 84/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|8/28|
|bone|4/26|
|breast|3/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|4/20|
|lung|9/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|5/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 543
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRA2B Expression in NALM6 Cells: 8.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>