TRAF3 [The Human Chemical-Genetic Interaction Map Project]

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======= TRAF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAF3
  * **<color #00a2e8>Official Name</color>**: TNF receptor associated factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7187|7187]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13114|Q13114]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601896|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MATH|
|zf-TRAF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Toll signaling pathway|
|CD40 receptor complex|
|thioesterase binding|
|TRIF-dependent toll-like receptor signaling pathway|
|tumor necrosis factor receptor binding|
|MyD88-independent toll-like receptor signaling pathway|
|regulation of interferon-beta production|
|cytoplasmic side of plasma membrane|
|regulation of defense response to virus|
|negative regulation of NF-kappaB transcription factor activity|
|protein phosphatase binding|
|toll-like receptor signaling pathway|
|tumor necrosis factor-mediated signaling pathway|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|negative regulation of DNA-binding transcription factor activity|
|innate immune response-activating signal transduction|
|cellular response to tumor necrosis factor|
|ubiquitin-protein transferase activity|
|activation of innate immune response|
|response to tumor necrosis factor|
|endosome|
|protein deubiquitination|
|ubiquitin protein ligase binding|
|protein modification by small protein removal|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|regulation of DNA-binding transcription factor activity|
|regulation of innate immune response|
|protein kinase binding|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|protein-containing complex|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|cytokine-mediated signaling pathway|
|protein ubiquitination|
|regulation of cytokine production|
|regulation of proteolysis|
|regulation of defense response|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|zinc ion binding|
|positive regulation of immune response|
|apoptotic process|
|defense response to other organism|
|protein modification by small protein conjugation or removal|
|cellular response to cytokine stimulus|
|programmed cell death|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|mitochondrion|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of immune system process|
|regulation of cell death|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.33|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.84|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.8|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.74|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14846
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAF3 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>