TRAF5 [The Human Chemical-Genetic Interaction Map Project]

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======= TRAF5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAF5
  * **<color #00a2e8>Official Name</color>**: TNF receptor associated factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7188|7188]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00463|O00463]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAF5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAF5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602356|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. {ECO:0000269|PubMed:15121867}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-TRAF|
|MATH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD40 receptor complex|
|thioesterase binding|
|tumor necrosis factor receptor binding|
|cytoplasmic side of plasma membrane|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of DNA-binding transcription factor activity|
|ubiquitin protein ligase binding|
|regulation of DNA-binding transcription factor activity|
|centrosome|
|protein-containing complex|
|zinc ion binding|
|apoptotic process|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|identical protein binding|
|cell death|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.88|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18827
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAF5 Expression in NALM6 Cells: 4.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>