TRAIP [The Human Chemical-Genetic Interaction Map Project]

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======= TRAIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAIP
  * **<color #00a2e8>Official Name</color>**: TRAF interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10293|10293]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BWF2|Q9BWF2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605958|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity) (PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase (PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys- 63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is controversial (PubMed:26595769). {ECO:0000250|UniProtKB:Q8VIG6, ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:26595769, ECO:0000303|PubMed:26595769}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interferon-beta production|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of type I interferon production|
|regulation of interferon-beta production|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of type I interferon production|
|negative regulation of DNA-binding transcription factor activity|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|ubiquitin protein ligase activity|
|negative regulation of cytokine production|
|regulation of DNA-binding transcription factor activity|
|protein ubiquitination|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|protein modification by small protein conjugation|
|nucleolus|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|programmed cell death|
|cell death|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.28|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.21|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.2|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.15|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.86|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.86|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.77|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.72|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.73|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.75|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.84|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.91|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.92|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.96|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.99|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.25|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.32|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.588|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.532|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.523|
|[[:human genes:p:pola2|POLA2]]|0.507|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.5|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.491|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.481|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.481|
|[[:human genes:o:orc1|ORC1]]|0.481|
|[[:human genes:t:tceb3c|TCEB3C]]|0.48|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.478|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.478|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.478|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.477|
|[[:human genes:m:med17|MED17]]|0.473|
|[[:human genes:u:upf1|UPF1]]|0.472|
|[[:human genes:p:psmb2|PSMB2]]|0.47|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.468|
|[[:human genes:p:psmb4|PSMB4]]|0.456|
|[[:human genes:r:rpa2|RPA2]]|0.454|
|[[:human genes:r:rbm39|RBM39]]|0.454|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.454|
|[[:human genes:e:exosc8|EXOSC8]]|0.453|
|[[:human genes:z:zfand5|ZFAND5]]|0.453|
|[[:human genes:p:psmd3|PSMD3]]|0.453|
|[[:human genes:i:igfn1|IGFN1]]|0.452|
|[[:human genes:s:ssh2|SSH2]]|0.451|
|[[:human genes:c:cdc45|CDC45]]|0.45|
|[[:human genes:s:smg1|SMG1]]|0.446|
|[[:human genes:k:kctd17|KCTD17]]|0.446|
|[[:human genes:p:psma7|PSMA7]]|0.445|
|[[:human genes:n:nupl1|NUPL1]]|0.445|
|[[:human genes:e:elmod3|ELMOD3]]|0.443|
|[[:human genes:n:nfatc4|NFATC4]]|0.443|
|[[:human genes:v:vasn|VASN]]|0.442|
|[[:human genes:p:pcf11|PCF11]]|0.442|
|[[:human genes:p:pan3|PAN3]]|0.441|
|[[:human genes:r:rad51|RAD51]]|0.441|
|[[:human genes:r:rps12|RPS12]]|0.44|
|[[:human genes:r:rad21|RAD21]]|0.44|
|[[:human genes:p:psma6|PSMA6]]|0.439|
|[[:human genes:s:supt6h|SUPT6H]]|0.437|
|[[:human genes:t:twistnb|TWISTNB]]|0.436|
|[[:human genes:t:timeless|TIMELESS]]|0.435|
|[[:human genes:m:mt1e|MT1E]]|0.435|
|[[:human genes:s:slc38a7|SLC38A7]]|0.434|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.433|
|[[:human genes:d:ddtl|DDTL]]|0.433|
|[[:human genes:s:sec13|SEC13]]|0.432|
|[[:human genes:p:psmd11|PSMD11]]|0.431|
|[[:human genes:p:polr1a|POLR1A]]|0.431|
|[[:human genes:s:smg7|SMG7]]|0.429|
|[[:human genes:c:chd4|CHD4]]|0.429|
|[[:human genes:c:cbwd3|CBWD3]]|0.429|
|[[:human genes:c:cbwd5|CBWD5]]|0.429|
|[[:human genes:w:wdr75|WDR75]]|0.428|
|[[:human genes:r:rps2|RPS2]]|0.426|
|[[:human genes:t:ticrr|TICRR]]|0.425|
|[[:human genes:t:top1mt|TOP1MT]]|0.424|
|[[:human genes:p:psmd1|PSMD1]]|0.423|
|[[:human genes:h:hivep3|HIVEP3]]|0.423|
|[[:human genes:p:polr2d|POLR2D]]|0.421|
|[[:human genes:x:xab2|XAB2]]|0.42|
|[[:human genes:z:znf655|ZNF655]]|0.419|
|[[:human genes:a:atp13a1|ATP13A1]]|0.419|
|[[:human genes:z:znf106|ZNF106]]|0.418|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.418|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.417|
|[[:human genes:i:iscu|ISCU]]|0.417|
|[[:human genes:d:ddx56|DDX56]]|0.416|
|[[:human genes:r:rpl30|RPL30]]|0.416|
|[[:human genes:a:aqr|AQR]]|0.415|
|[[:human genes:p:prim1|PRIM1]]|0.415|
|[[:human genes:d:dido1|DIDO1]]|0.415|
|[[:human genes:u:uqcrh|UQCRH]]|0.414|
|[[:human genes:m:mdm2|MDM2]]|0.412|
|[[:human genes:r:rpl35|RPL35]]|0.411|
|[[:human genes:o:orc6|ORC6]]|0.411|
|[[:human genes:d:dtl|DTL]]|0.41|
|[[:human genes:c:copg1|COPG1]]|0.409|
|[[:human genes:p:psap|PSAP]]|0.409|
|[[:human genes:s:slc4a1|SLC4A1]]|0.407|
|[[:human genes:c:cdca3|CDCA3]]|0.407|
|[[:human genes:s:scaf1|SCAF1]]|0.407|
|[[:human genes:n:narfl|NARFL]]|0.406|
|[[:human genes:r:rps14|RPS14]]|0.405|
|[[:human genes:p:pola1|POLA1]]|0.405|
|[[:human genes:r:rps28|RPS28]]|0.405|
|[[:human genes:p:psmc6|PSMC6]]|0.405|
|[[:human genes:c:ctr9|CTR9]]|0.404|
|[[:human genes:m:med12|MED12]]|0.403|
|[[:human genes:a:akirin2|AKIRIN2]]|0.403|
|[[:human genes:m:madcam1|MADCAM1]]|0.402|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.402|
|[[:human genes:p:psmc2|PSMC2]]|0.402|
|[[:human genes:c:ccna2|CCNA2]]|0.401|
|[[:human genes:r:rrp7a|RRP7A]]|0.401|
|[[:human genes:p:psmd7|PSMD7]]|0.401|
|[[:human genes:n:nup133|NUP133]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 485/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|20/28|
|bone|23/26|
|breast|27/33|
|central nervous system|33/56|
|cervix|2/4|
|colorectal|11/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|12/21|
|liver|9/20|
|lung|50/75|
|lymphocyte|10/16|
|ovary|18/26|
|pancreas|14/24|
|peripheral nervous system|12/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|21/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 369
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAIP Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>