TRAK1 [The Human Chemical-Genetic Interaction Map Project]

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======= TRAK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAK1
  * **<color #00a2e8>Official Name</color>**: trafficking kinesin protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22906|22906]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPV9|Q9UPV9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608112|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. {ECO:0000269|PubMed:18675823}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Milton|
|HAP1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anterograde axonal transport of mitochondrion|
|TPR domain binding|
|axonal transport of mitochondrion|
|GABA receptor binding|
|mitochondrion distribution|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization, microtubule-mediated|
|myosin binding|
|establishment of mitochondrion localization|
|axonal growth cone|
|vesicle transport along microtubule|
|anterograde axonal transport|
|mitochondrion localization|
|vesicle cytoskeletal trafficking|
|endosome to lysosome transport|
|axonal transport|
|axon cytoplasm|
|dendrite morphogenesis|
|axo-dendritic transport|
|organelle transport along microtubule|
|positive regulation of axonogenesis|
|mitochondrial membrane|
|dendrite development|
|lysosomal transport|
|protein O-linked glycosylation|
|cell cortex|
|vacuolar transport|
|positive regulation of cell morphogenesis involved in differentiation|
|transport along microtubule|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|vesicle localization|
|regulation of axonogenesis|
|cytoplasmic vesicle|
|early endosome|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|microtubule-based movement|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|glycoprotein biosynthetic process|
|signaling receptor binding|
|protein targeting|
|establishment of organelle localization|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|glycoprotein metabolic process|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|mitochondrion organization|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell morphogenesis involved in differentiation|
|organelle localization|
|carbohydrate derivative biosynthetic process|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|intracellular protein transport|
|neuron differentiation|
|carbohydrate derivative metabolic process|
|regulation of anatomical structure morphogenesis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|mitochondrion|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.45|
|[[:human genes:h:hars|HARS]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11827
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAK1 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>