TRAPPC11 [The Human Chemical-Genetic Interaction Map Project]

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======= TRAPPC11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAPPC11
  * **<color #00a2e8>Official Name</color>**: trafficking protein particle complex 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60684|60684]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z392|Q7Z392]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAPPC11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAPPC11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614138|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Foie-gras 1|
|Gryzun-like|
|Gryzun|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein complex stability|
|TRAPP complex|
|Golgi organization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|endomembrane system organization|
|protein complex oligomerization|
|Golgi apparatus|
|intracellular transport|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.34|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.16|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.15|
|[[:results:exp539|42°C R08 exp539]]|-1.85|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.84|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.659|
|[[:human genes:v:vps28|VPS28]]|0.513|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.489|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.461|
|[[:human genes:n:napa|NAPA]]|0.459|
|[[:human genes:c:copg1|COPG1]]|0.447|
|[[:human genes:v:vps54|VPS54]]|0.446|
|[[:human genes:t:trappc8|TRAPPC8]]|0.445|
|[[:human genes:v:vps52|VPS52]]|0.443|
|[[:human genes:n:nsf|NSF]]|0.44|
|[[:human genes:c:copz1|COPZ1]]|0.438|
|[[:human genes:t:trappc2l|TRAPPC2L]]|0.435|
|[[:human genes:c:cbwd5|CBWD5]]|0.433|
|[[:human genes:t:tfip11|TFIP11]]|0.431|
|[[:human genes:c:cbwd3|CBWD3]]|0.428|
|[[:human genes:c:chd4|CHD4]]|0.428|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.426|
|[[:human genes:z:znf830|ZNF830]]|0.424|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.422|
|[[:human genes:t:timeless|TIMELESS]]|0.422|
|[[:human genes:k:krt2|KRT2]]|0.422|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.421|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.421|
|[[:human genes:a:atp6v1e1|ATP6V1E1]]|0.419|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.418|
|[[:human genes:s:supt5h|SUPT5H]]|0.417|
|[[:human genes:c:cbwd6|CBWD6]]|0.417|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.416|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.415|
|[[:human genes:s:sart1|SART1]]|0.414|
|[[:human genes:c:copa|COPA]]|0.413|
|[[:human genes:p:polr2d|POLR2D]]|0.412|
|[[:human genes:a:arcn1|ARCN1]]|0.41|
|[[:human genes:t:tceb3c|TCEB3C]]|0.409|
|[[:human genes:t:tsg101|TSG101]]|0.408|
|[[:human genes:r:rps10|RPS10]]|0.408|
|[[:human genes:e:exosc3|EXOSC3]]|0.408|
|[[:human genes:m:myb|MYB]]|0.408|
|[[:human genes:e:exosc8|EXOSC8]]|0.407|
|[[:human genes:r:rrp7a|RRP7A]]|0.407|
|[[:human genes:c:chaf1a|CHAF1A]]|0.407|
|[[:human genes:e:exosc9|EXOSC9]]|0.405|
|[[:human genes:r:rad51|RAD51]]|0.405|
|[[:human genes:k:krt78|KRT78]]|0.404|
|[[:human genes:v:vps53|VPS53]]|0.404|
|[[:human genes:a:aatf|AATF]]|0.403|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.402|
|[[:human genes:x:xab2|XAB2]]|0.402|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.401|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.401|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.401|
|[[:human genes:c:chmp4b|CHMP4B]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 531/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|22/28|
|blood|17/28|
|bone|23/26|
|breast|20/33|
|central nervous system|50/56|
|cervix|3/4|
|colorectal|11/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|18/21|
|liver|18/20|
|lung|51/75|
|lymphocyte|11/16|
|ovary|23/26|
|pancreas|14/24|
|peripheral nervous system|10/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|19/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1048
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAPPC11 Expression in NALM6 Cells: 5.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>