TRAPPC9 [The Human Chemical-Genetic Interaction Map Project]

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======= TRAPPC9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAPPC9
  * **<color #00a2e8>Official Name</color>**: trafficking protein particle complex 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83696|83696]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96Q05|Q96Q05]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAPPC9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAPPC9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611966|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that likely plays a role in NF-kappa-B signaling. Mutations in this gene have been associated with autosomal-recessive cognitive disability. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRAPPC9-Trs120|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAPP complex|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|vesicle targeting|
|vesicle budding from membrane|
|cerebral cortex development|
|positive regulation of NF-kappaB transcription factor activity|
|trans-Golgi network|
|pallium development|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|telencephalon development|
|positive regulation of DNA-binding transcription factor activity|
|vesicle organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|forebrain development|
|regulation of DNA-binding transcription factor activity|
|organelle localization|
|Golgi membrane|
|brain development|
|head development|
|membrane organization|
|central nervous system development|
|endoplasmic reticulum|
|neuron differentiation|
|intracellular transport|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|positive regulation of molecular function|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.06|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.07|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|4.15|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|4.38|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|4.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rab11a|RAB11A]]|0.582|
|[[:human genes:t:trappc10|TRAPPC10]]|0.535|
|[[:human genes:p:pitpnb|PITPNB]]|0.426|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5632
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAPPC9 Expression in NALM6 Cells: 4.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>