TRH [The Human Chemical-Genetic Interaction Map Project]

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======= TRH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRH
  * **<color #00a2e8>Official Name</color>**: thyrotropin releasing hormone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7200|7200]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20396|P20396]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613879|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. {ECO:0000269|PubMed:19825978}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thyrotropin-releasing hormone activity|
|positive regulation of gamma-aminobutyric acid secretion|
|histamine metabolic process|
|negative regulation of glutamate secretion|
|regulation of gamma-aminobutyric acid secretion|
|negative regulation of feeding behavior|
|negative regulation of amino acid transport|
|imidazole-containing compound metabolic process|
|regulation of glutamate secretion|
|negative regulation of behavior|
|positive regulation of amino acid transport|
|negative regulation of organic acid transport|
|response to corticosterone|
|negative regulation of amine transport|
|regulation of feeding behavior|
|negative regulation of anion transport|
|eating behavior|
|adult walking behavior|
|walking behavior|
|regulation of amino acid transport|
|response to mineralocorticoid|
|positive regulation of organic acid transport|
|positive regulation of amine transport|
|positive regulation of neurotransmitter transport|
|response to cold|
|positive regulation of anion transport|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|regulation of organic acid transport|
|amine metabolic process|
|positive regulation of insulin secretion|
|regulation of behavior|
|adult locomotory behavior|
|feeding behavior|
|secretory granule|
|neurotransmitter metabolic process|
|regulation of amine transport|
|regulation of anion transport|
|positive regulation of peptide hormone secretion|
|response to ethanol|
|positive regulation of hormone secretion|
|response to glucose|
|regulation of neurotransmitter transport|
|response to hexose|
|response to glucocorticoid|
|adult behavior|
|negative regulation of ion transport|
|response to monosaccharide|
|response to corticosteroid|
|hormone-mediated signaling pathway|
|response to carbohydrate|
|response to temperature stimulus|
|regulation of insulin secretion|
|response to ketone|
|ammonium ion metabolic process|
|locomotory behavior|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|negative regulation of secretion|
|response to alcohol|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of ion transport|
|positive regulation of peptide secretion|
|response to antibiotic|
|response to steroid hormone|
|response to hypoxia|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|response to oxygen levels|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|response to toxic substance|
|regulation of hormone levels|
|behavior|
|cellular response to hormone stimulus|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|positive regulation of transport|
|response to drug|
|regulation of protein localization|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14238
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRH Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>