TRIM37 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM37 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM37
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 37
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4591|4591]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94972|O94972]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM37&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM37|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605073|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aggresome assembly|
|inclusion body assembly|
|negative regulation of centriole replication|
|histone H2A-K119 monoubiquitination|
|negative regulation of centrosome duplication|
|negative regulation of centrosome cycle|
|ESC/E(Z) complex|
|histone H2A monoubiquitination|
|regulation of centriole replication|
|histone H2A ubiquitination|
|histone monoubiquitination|
|tumor necrosis factor receptor binding|
|negative regulation of organelle assembly|
|histone ubiquitination|
|aggresome|
|regulation of centrosome duplication|
|regulation of centrosome cycle|
|protein monoubiquitination|
|protein autoubiquitination|
|negative regulation of NF-kappaB transcription factor activity|
|peroxisome|
|negative regulation of cytoskeleton organization|
|positive regulation of NF-kappaB transcription factor activity|
|negative regulation of DNA-binding transcription factor activity|
|regulation of microtubule cytoskeleton organization|
|regulation of organelle assembly|
|ubiquitin protein ligase activity|
|regulation of microtubule-based process|
|ubiquitin-protein transferase activity|
|positive regulation of DNA-binding transcription factor activity|
|ubiquitin protein ligase binding|
|negative regulation of cell cycle process|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|chromatin binding|
|regulation of DNA-binding transcription factor activity|
|regulation of cytoskeleton organization|
|negative regulation of cell cycle|
|protein ubiquitination|
|perinuclear region of cytoplasm|
|chromatin organization|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.73|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.77|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.87|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.9|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.95|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.02|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|2/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6905
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM37 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>