TRIM44 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM44 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM44
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 44
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54765|54765]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DX7|Q96DX7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM44&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM44|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612298|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807). {ECO:0000250, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:26394807}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein K48-linked ubiquitination|
|regulation of protein K48-linked ubiquitination|
|negative regulation of protein polyubiquitination|
|regulation of protein polyubiquitination|
|positive regulation of defense response to virus by host|
|regulation of defense response to virus by host|
|positive regulation of cytokine-mediated signaling pathway|
|positive regulation of response to cytokine stimulus|
|regulation of defense response to virus|
|negative regulation of protein ubiquitination|
|positive regulation of NIK/NF-kappaB signaling|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of NIK/NF-kappaB signaling|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|protein stabilization|
|regulation of protein ubiquitination|
|regulation of protein modification by small protein conjugation or removal|
|regulation of protein stability|
|regulation of immune effector process|
|regulation of response to biotic stimulus|
|negative regulation of protein modification process|
|regulation of defense response|
|regulation of multi-organism process|
|zinc ion binding|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.82|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2.62|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.5|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-2.37|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.27|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.25|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.07|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.06|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.04|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.98|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.97|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.97|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.86|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.85|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.84|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.78|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.74|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.7|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.7|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.71|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.72|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.75|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.79|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.79|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.86|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.99|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|2.32|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.52|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.93|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|3.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9398
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM44 Expression in NALM6 Cells: 8.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>