TRIM6 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM6
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=117854|117854]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C030|Q9C030]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607564|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218). {ECO:0000250|UniProtKB:Q8BGE7, ECO:0000269|PubMed:24882218}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
|zf-B box|
|SPRY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|free ubiquitin chain polymerization|
|positive regulation of cytokine secretion involved in immune response|
|ubiquitin recycling|
|positive regulation of type I interferon-mediated signaling pathway|
|regulation of cytokine secretion involved in immune response|
|cellular response to interferon-beta|
|negative regulation of stem cell differentiation|
|positive regulation of transcription regulatory region DNA binding|
|positive regulation of defense response to virus by host|
|protein tyrosine kinase binding|
|response to interferon-beta|
|positive regulation of peptidyl-threonine phosphorylation|
|cellular response to virus|
|regulation of type I interferon-mediated signaling pathway|
|regulation of defense response to virus by host|
|regulation of peptidyl-threonine phosphorylation|
|positive regulation of cytokine-mediated signaling pathway|
|regulation of transcription regulatory region DNA binding|
|positive regulation of cytokine production involved in immune response|
|protein trimerization|
|positive regulation of DNA binding|
|positive regulation of response to cytokine stimulus|
|negative regulation of viral genome replication|
|regulation of defense response to virus|
|protein binding, bridging|
|negative regulation of viral life cycle|
|regulation of cytokine production involved in immune response|
|protein polymerization|
|regulation of viral genome replication|
|positive regulation of production of molecular mediator of immune response|
|negative regulation of viral process|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of NIK/NF-kappaB signaling|
|regulation of stem cell differentiation|
|regulation of DNA binding|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|regulation of viral life cycle|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|positive regulation of binding|
|regulation of cytokine secretion|
|regulation of viral process|
|negative regulation of multi-organism process|
|positive regulation of immune effector process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|ubiquitin protein ligase activity|
|positive regulation of protein secretion|
|response to virus|
|positive regulation of peptide secretion|
|protein polyubiquitination|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|transcription factor binding|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|regulation of binding|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of peptide secretion|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|protein ubiquitination|
|response to bacterium|
|regulation of cytokine production|
|viral process|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|zinc ion binding|
|cellular protein-containing complex assembly|
|response to lipid|
|positive regulation of immune response|
|cellular homeostasis|
|negative regulation of developmental process|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9174
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM6 Expression in NALM6 Cells: 3.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>