TRIOBP [The Human Chemical-Genetic Interaction Map Project]

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======= TRIOBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIOBP
  * **<color #00a2e8>Official Name</color>**: TRIO and F-actin binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11078|11078]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2D6|Q9H2D6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIOBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIOBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609761|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin modification|
|myosin II binding|
|auditory receptor cell stereocilium organization|
|auditory receptor cell morphogenesis|
|barbed-end actin filament capping|
|auditory receptor cell development|
|GTP-Rho binding|
|inner ear auditory receptor cell differentiation|
|inner ear receptor cell stereocilium organization|
|actin filament capping|
|hair cell differentiation|
|negative regulation of actin filament depolymerization|
|positive regulation of substrate adhesion-dependent cell spreading|
|inner ear receptor cell development|
|neuroepithelial cell differentiation|
|columnar/cuboidal epithelial cell development|
|regulation of actin filament depolymerization|
|inner ear receptor cell differentiation|
|regulation of substrate adhesion-dependent cell spreading|
|negative regulation of actin filament polymerization|
|mechanoreceptor differentiation|
|negative regulation of protein depolymerization|
|negative regulation of protein polymerization|
|negative regulation of protein complex disassembly|
|regulation of protein depolymerization|
|columnar/cuboidal epithelial cell differentiation|
|inner ear morphogenesis|
|regulation of protein complex disassembly|
|ear morphogenesis|
|positive regulation of cell-substrate adhesion|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|sensory perception of sound|
|positive regulation of cell morphogenesis involved in differentiation|
|midbody|
|microtubule organizing center|
|regulation of actin filament polymerization|
|sensory perception of mechanical stimulus|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|epithelial cell development|
|inner ear development|
|actin filament binding|
|regulation of cell-substrate adhesion|
|actin cytoskeleton|
|ear development|
|regulation of protein polymerization|
|sensory organ morphogenesis|
|regulation of actin filament organization|
|embryonic organ morphogenesis|
|ubiquitin protein ligase binding|
|regulation of cell morphogenesis involved in differentiation|
|epidermal cell differentiation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|positive regulation of cell adhesion|
|epidermis development|
|focal adhesion|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|regulation of protein complex assembly|
|regulation of cell morphogenesis|
|cell division|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|actin filament-based process|
|neuron projection development|
|epithelial cell differentiation|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|regulation of cell development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|sensory perception|
|embryo development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|neurogenesis|
|cell development|
|tissue development|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.96|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.8|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.87|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.96|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5664
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIOBP Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>