TRMT61B [The Human Chemical-Genetic Interaction Map Project]

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======= TRMT61B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRMT61B
  * **<color #00a2e8>Official Name</color>**: tRNA methyltransferase 61B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55006|55006]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVS5|Q9BVS5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRMT61B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRMT61B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619404|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1- methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)- methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537). {ECO:0000269|PubMed:23097428, ECO:0000269|PubMed:27631568, ECO:0000269|PubMed:29107537}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 18|
|PCMT|
|GCD14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA (adenine) methyltransferase activity|
|tRNA (m1A) methyltransferase complex|
|mRNA (adenine-N1-)-methyltransferase activity|
|tRNA (adenine-N1-)-methyltransferase activity|
|mitochondrial tRNA methylation|
|mitochondrial tRNA modification|
|mitochondrial RNA modification|
|mitochondrial tRNA processing|
|mRNA methylation|
|tRNA threonylcarbamoyladenosine metabolic process|
|mitochondrial RNA processing|
|mRNA modification|
|rRNA methylation|
|rRNA modification|
|mitochondrial RNA metabolic process|
|tRNA methylation|
|RNA methylation|
|tRNA modification|
|tRNA processing|
|mitochondrial gene expression|
|RNA modification|
|tRNA metabolic process|
|rRNA processing|
|rRNA metabolic process|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|protein homooligomerization|
|mitochondrial matrix|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein complex oligomerization|
|mRNA metabolic process|
|RNA processing|
|mitochondrion|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.502|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4475
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRMT61B Expression in NALM6 Cells: 4.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>