TRNT1 [The Human Chemical-Genetic Interaction Map Project]

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======= TRNT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRNT1
  * **<color #00a2e8>Official Name</color>**: tRNA nucleotidyl transferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51095|51095]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96Q11|Q96Q11]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRNT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRNT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612907|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. {ECO:0000269|PubMed:11504732}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PolyA pol|
|PolyA pol RNAbd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATP:3-cytidine-cytidine-tRNA adenylyltransferase activity|
|CTP:tRNA cytidylyltransferase activity|
|CTP:3-cytidine-tRNA cytidylyltransferase activity|
|tRNA 3-terminal CCA addition|
|5-3 RNA polymerase activity|
|mitochondrial tRNA 3-end processing|
|mitochondrial RNA 3-end processing|
|tRNA 3-end processing|
|mitochondrial tRNA processing|
|mitochondrial RNA processing|
|mitochondrial RNA metabolic process|
|ncRNA 3-end processing|
|tRNA binding|
|intracellular|
|tRNA processing|
|RNA 3-end processing|
|mitochondrial gene expression|
|tRNA metabolic process|
|mitochondrial matrix|
|ncRNA processing|
|ncRNA metabolic process|
|RNA processing|
|mitochondrion|
|ATP binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.74|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.72|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.75|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.94|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.629|
|[[:human genes:t:triap1|TRIAP1]]|0.597|
|[[:human genes:r:rnmt|RNMT]]|0.593|
|[[:human genes:r:rptor|RPTOR]]|0.575|
|[[:human genes:d:dpagt1|DPAGT1]]|0.57|
|[[:human genes:a:alg1|ALG1]]|0.568|
|[[:human genes:d:dohh|DOHH]]|0.558|
|[[:human genes:u:uap1|UAP1]]|0.552|
|[[:human genes:a:alg13|ALG13]]|0.55|
|[[:human genes:p:pmm2|PMM2]]|0.547|
|[[:human genes:g:gmppb|GMPPB]]|0.546|
|[[:human genes:p:polr3h|POLR3H]]|0.53|
|[[:human genes:a:atxn10|ATXN10]]|0.517|
|[[:human genes:r:rtcb|RTCB]]|0.517|
|[[:human genes:g:gfpt1|GFPT1]]|0.516|
|[[:human genes:w:wdr24|WDR24]]|0.512|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.508|
|[[:human genes:p:ppcs|PPCS]]|0.504|
|[[:human genes:a:atp5b|ATP5B]]|0.504|
|[[:human genes:v:vezt|VEZT]]|0.499|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.496|
|[[:human genes:n:nae1|NAE1]]|0.493|
|[[:human genes:g:gnb1l|GNB1L]]|0.493|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.492|
|[[:human genes:o:oraov1|ORAOV1]]|0.491|
|[[:human genes:e:exoc4|EXOC4]]|0.487|
|[[:human genes:r:romo1|ROMO1]]|0.484|
|[[:human genes:a:atp5o|ATP5O]]|0.483|
|[[:human genes:t:tamm41|TAMM41]]|0.483|
|[[:human genes:r:rpp21|RPP21]]|0.481|
|[[:human genes:m:med16|MED16]]|0.479|
|[[:human genes:t:taz|TAZ]]|0.476|
|[[:human genes:t:telo2|TELO2]]|0.474|
|[[:human genes:a:adsl|ADSL]]|0.474|
|[[:human genes:t:trmt5|TRMT5]]|0.473|
|[[:human genes:w:wdr59|WDR59]]|0.471|
|[[:human genes:g:gemin6|GEMIN6]]|0.469|
|[[:human genes:s:ssb|SSB]]|0.468|
|[[:human genes:h:hccs|HCCS]]|0.467|
|[[:human genes:p:polr3b|POLR3B]]|0.467|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.466|
|[[:human genes:c:chchd4|CHCHD4]]|0.465|
|[[:human genes:p:pelo|PELO]]|0.463|
|[[:human genes:d:dr1|DR1]]|0.462|
|[[:human genes:h:hspd1|HSPD1]]|0.462|
|[[:human genes:c:cbfb|CBFB]]|0.46|
|[[:human genes:u:uhrf1|UHRF1]]|0.459|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.458|
|[[:human genes:p:pdss1|PDSS1]]|0.457|
|[[:human genes:m:meaf6|MEAF6]]|0.455|
|[[:human genes:u:utp23|UTP23]]|0.454|
|[[:human genes:a:alg2|ALG2]]|0.453|
|[[:human genes:m:mtor|MTOR]]|0.451|
|[[:human genes:b:bap1|BAP1]]|0.451|
|[[:human genes:s:sec61g|SEC61G]]|0.45|
|[[:human genes:s:sdha|SDHA]]|0.45|
|[[:human genes:u:urm1|URM1]]|0.45|
|[[:human genes:a:atp5d|ATP5D]]|0.449|
|[[:human genes:s:slc25a26|SLC25A26]]|0.447|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.447|
|[[:human genes:f:fnta|FNTA]]|0.445|
|[[:human genes:c:c17orf89|C17orf89]]|0.445|
|[[:human genes:s:srp14|SRP14]]|0.444|
|[[:human genes:t:tmem41b|TMEM41B]]|0.439|
|[[:human genes:f:fh|FH]]|0.437|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.437|
|[[:human genes:d:dhps|DHPS]]|0.436|
|[[:human genes:c:csnk2b|CSNK2B]]|0.433|
|[[:human genes:t:tsen54|TSEN54]]|0.431|
|[[:human genes:e:eif4e|EIF4E]]|0.431|
|[[:human genes:m:med23|MED23]]|0.429|
|[[:human genes:a:atp5j|ATP5J]]|0.429|
|[[:human genes:s:srprb|SRPRB]]|0.427|
|[[:human genes:a:aars|AARS]]|0.427|
|[[:human genes:c:crls1|CRLS1]]|0.425|
|[[:human genes:d:dars2|DARS2]]|0.425|
|[[:human genes:t:trmt10a|TRMT10A]]|0.424|
|[[:human genes:p:pam16|PAM16]]|0.422|
|[[:human genes:e:eif3f|EIF3F]]|0.422|
|[[:human genes:c:ccdc101|CCDC101]]|0.422|
|[[:human genes:t:tti2|TTI2]]|0.422|
|[[:human genes:r:rpia|RPIA]]|0.421|
|[[:human genes:s:ssbp2|SSBP2]]|0.421|
|[[:human genes:m:mlst8|MLST8]]|0.42|
|[[:human genes:t:ttc4|TTC4]]|0.42|
|[[:human genes:p:ppa2|PPA2]]|0.418|
|[[:human genes:v:vps41|VPS41]]|0.417|
|[[:human genes:s:sars2|SARS2]]|0.416|
|[[:human genes:d:ddx20|DDX20]]|0.416|
|[[:human genes:u:uba3|UBA3]]|0.415|
|[[:human genes:g:gemin8|GEMIN8]]|0.414|
|[[:human genes:r:rpn1|RPN1]]|0.414|
|[[:human genes:t:tufm|TUFM]]|0.414|
|[[:human genes:a:atp5a1|ATP5A1]]|0.413|
|[[:human genes:c:crcp|CRCP]]|0.413|
|[[:human genes:d:dad1|DAD1]]|0.413|
|[[:human genes:u:ube2g2|UBE2G2]]|0.412|
|[[:human genes:b:bcs1l|BCS1L]]|0.412|
|[[:human genes:t:txnl4b|TXNL4B]]|0.411|
|[[:human genes:y:yars|YARS]]|0.411|
|[[:human genes:v:vmp1|VMP1]]|0.41|
|[[:human genes:w:wdr82|WDR82]]|0.409|
|[[:human genes:k:kdsr|KDSR]]|0.408|
|[[:human genes:d:ddx55|DDX55]]|0.408|
|[[:human genes:u:ube2m|UBE2M]]|0.408|
|[[:human genes:m:mllt1|MLLT1]]|0.408|
|[[:human genes:d:dolk|DOLK]]|0.406|
|[[:human genes:m:med4|MED4]]|0.406|
|[[:human genes:m:mbtps2|MBTPS2]]|0.406|
|[[:human genes:e:elac2|ELAC2]]|0.406|
|[[:human genes:t:timm13|TIMM13]]|0.405|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.405|
|[[:human genes:o:otud5|OTUD5]]|0.402|
|[[:human genes:a:alg5|ALG5]]|0.402|
|[[:human genes:t:tbca|TBCA]]|0.402|
|[[:human genes:s:sec62|SEC62]]|0.402|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.402|
|[[:human genes:d:dnlz|DNLZ]]|0.401|
|[[:human genes:l:lsm11|LSM11]]|0.401|
|[[:human genes:c:casp9|CASP9]]|0.401|
|[[:human genes:n:nars|NARS]]|0.401|
|[[:human genes:h:haus8|HAUS8]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 729/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|31/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 566
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRNT1 Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>