TRPV1 [The Human Chemical-Genetic Interaction Map Project]

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======= TRPV1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRPV1
  * **<color #00a2e8>Official Name</color>**: transient receptor potential cation channel subfamily V member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7442|7442]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NER1|Q8NER1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRPV1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRPV1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602076|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. {ECO:0000250|UniProtKB:O35433, ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11226139, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:12077606}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ion trans|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|temperature-gated ion channel activity|
|excitatory extracellular ligand-gated ion channel activity|
|detection of temperature stimulus involved in thermoception|
|response to capsazepine|
|negative regulation of establishment of blood-brain barrier|
|positive regulation of gastric acid secretion|
|smooth muscle contraction involved in micturition|
|thermoception|
|detection of chemical stimulus involved in sensory perception of pain|
|fever generation|
|regulation of establishment of blood-brain barrier|
|heat generation|
|cellular response to temperature stimulus|
|micturition|
|chloride channel regulator activity|
|urinary tract smooth muscle contraction|
|urinary bladder smooth muscle contraction|
|calcium ion import across plasma membrane|
|positive regulation of digestive system process|
|calcium ion import into cytosol|
|negative regulation of heart rate|
|regulation of gastric acid secretion|
|negative regulation of mitochondrial membrane potential|
|cellular response to acidic pH|
|diet induced thermogenesis|
|negative regulation of membrane potential|
|dendritic spine membrane|
|calcium-release channel activity|
|behavioral response to pain|
|detection of temperature stimulus involved in sensory perception of pain|
|detection of temperature stimulus involved in sensory perception|
|chemosensory behavior|
|negative regulation of systemic arterial blood pressure|
|cellular response to ATP|
|detection of temperature stimulus|
|adaptive thermogenesis|
|sensory perception of temperature stimulus|
|cellular response to pH|
|response to acidic pH|
|negative regulation of heart contraction|
|ion channel activity|
|response to dietary excess|
|glutamate secretion|
|leukocyte activation involved in inflammatory response|
|response to pain|
|temperature homeostasis|
|microglial cell activation|
|response to ATP|
|negative regulation of blood circulation|
|cellular response to alkaloid|
|phosphoprotein binding|
|intrinsic component of plasma membrane|
|glial cell activation|
|positive regulation of nitric oxide biosynthetic process|
|response to pH|
|positive regulation of nitric oxide metabolic process|
|acute-phase response|
|regulation of digestive system process|
|excretion|
|neuroinflammatory response|
|calcium ion import|
|negative regulation of blood pressure|
|acidic amino acid transport|
|extracellular ligand-gated ion channel activity|
|cellular response to nerve growth factor stimulus|
|macrophage activation|
|positive regulation of reactive oxygen species biosynthetic process|
|response to nerve growth factor|
|smooth muscle contraction|
|calcium channel activity|
|release of sequestered calcium ion into cytosol|
|regulation of nitric oxide biosynthetic process|
|negative regulation of sequestering of calcium ion|
|excitatory postsynaptic potential|
|calcium ion transmembrane import into cytosol|
|cellular response to nutrient|
|chemical synaptic transmission, postsynaptic|
|multicellular organismal response to stress|
|cellular response to heat|
|regulation of mitochondrial membrane potential|
|acute inflammatory response|
|calcium ion transport into cytosol|
|sensory perception of pain|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|dicarboxylic acid transport|
|acid secretion|
|regulation of reactive oxygen species biosynthetic process|
|phosphatidylinositol binding|
|cytosolic calcium ion transport|
|protein homotetramerization|
|regulation of systemic arterial blood pressure|
|positive regulation of reactive oxygen species metabolic process|
|import across plasma membrane|
|regulation of heart rate|
|regulation of postsynaptic membrane potential|
|response to heat|
|renal system process|
|response to alkaloid|
|amino acid transport|
|detection of external stimulus|
|detection of abiotic stimulus|
|regulation of sequestering of calcium ion|
|response to organophosphorus|
|transmembrane signaling receptor activity|
|protein tetramerization|
|response to purine-containing compound|
|sensory perception of mechanical stimulus|
|peptide secretion|
|response to temperature stimulus|
|regulation of reactive oxygen species metabolic process|
|regulation of blood pressure|
|calcium ion transmembrane transport|
|postsynaptic membrane|
|calmodulin binding|
|response to nutrient|
|cellular response to nutrient levels|
|cellular response to tumor necrosis factor|
|regulation of heart contraction|
|calcium ion transport|
|muscle contraction|
|response to tumor necrosis factor|
|cellular response to extracellular stimulus|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|organic acid transport|
|carboxylic acid transport|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|negative regulation of cell development|
|cellular response to external stimulus|
|protein homooligomerization|
|regulation of neurotransmitter levels|
|neuronal cell body|
|blood circulation|
|response to peptide hormone|
|external side of plasma membrane|
|circulatory system process|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|calcium ion homeostasis|
|organic anion transport|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|detection of chemical stimulus involved in sensory perception|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|inflammatory response|
|cellular response to growth factor stimulus|
|protein complex oligomerization|
|detection of chemical stimulus|
|response to extracellular stimulus|
|response to growth factor|
|sensory perception of chemical stimulus|
|cellular response to organic cyclic compound|
|detection of stimulus involved in sensory perception|
|cell junction|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|behavior|
|anion transport|
|myeloid leukocyte activation|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|import into cell|
|detection of stimulus|
|positive regulation of cell death|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|negative regulation of transcription by RNA polymerase II|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|ion transmembrane transport|
|sensory perception|
|positive regulation of transport|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|transmembrane transport|
|negative regulation of RNA metabolic process|
|defense response|
|ion transport|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6312
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRPV1 Expression in NALM6 Cells: 5.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>