TRPV6 [The Human Chemical-Genetic Interaction Map Project]

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======= TRPV6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRPV6
  * **<color #00a2e8>Official Name</color>**: transient receptor potential cation channel subfamily V member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55503|55503]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1D0|Q9H1D0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRPV6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRPV6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606680|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. Translation initiation for this protein occurs at a non-AUG start codon that is decoded as methionine. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Feb 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)- dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5- TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ion trans|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium ion import across plasma membrane|
|calcium ion import into cytosol|
|ion channel activity|
|regulation of calcium ion-dependent exocytosis|
|calcium ion import|
|calcium channel activity|
|calcium ion transmembrane import into cytosol|
|calcium ion transport into cytosol|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|cytosolic calcium ion transport|
|import across plasma membrane|
|response to calcium ion|
|regulation of regulated secretory pathway|
|calcium ion transmembrane transport|
|calmodulin binding|
|regulation of exocytosis|
|calcium ion transport|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|response to metal ion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to inorganic substance|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|homeostatic process|
|establishment of localization in cell|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11113
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRPV6 Expression in NALM6 Cells: -1.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>