TSC22D2 [The Human Chemical-Genetic Interaction Map Project]

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======= TSC22D2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSC22D2
  * **<color #00a2e8>Official Name</color>**: TSC22 domain family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9819|9819]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75157|O75157]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSC22D2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSC22D2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617724|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TSC22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to osmotic stress|
|response to abiotic stimulus|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.8|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.75|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.86|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.96|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.03|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.24|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.28|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.32|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.72|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.38|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rfwd2|RFWD2]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 18/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSC22D2 Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>