TSFM [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= TSFM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSFM
  * **<color #00a2e8>Official Name</color>**: Ts translation elongation factor, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10102|10102]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43897|P43897]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSFM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSFM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604723|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. {ECO:0000255|HAMAP-Rule:MF_03135, ECO:0000269|PubMed:27677415}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBA|
|EF TS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation elongation factor activity|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|regulation of DNA-templated transcription, elongation|
|mitochondrial translational elongation|
|mitochondrial translation|
|translational elongation|
|mitochondrial gene expression|
|regulation of translation|
|mitochondrial matrix|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.7|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.7|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.82|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.87|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mtif2|MTIF2]]|0.508|
|[[:human genes:a:acad9|ACAD9]]|0.488|
|[[:human genes:e:eral1|ERAL1]]|0.482|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.477|
|[[:human genes:s:sfxn4|SFXN4]]|0.473|
|[[:human genes:n:nsun4|NSUN4]]|0.459|
|[[:human genes:p:pet112|PET112]]|0.458|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.457|
|[[:human genes:p:pde12|PDE12]]|0.453|
|[[:human genes:n:nubpl|NUBPL]]|0.452|
|[[:human genes:m:mcat|MCAT]]|0.449|
|[[:human genes:n:ndufb10|NDUFB10]]|0.439|
|[[:human genes:m:mtg1|MTG1]]|0.436|
|[[:human genes:p:prepl|PREPL]]|0.434|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.423|
|[[:human genes:m:mterfd1|MTERFD1]]|0.422|
|[[:human genes:f:fastkd2|FASTKD2]]|0.421|
|[[:human genes:p:pet117|PET117]]|0.414|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.414|
|[[:human genes:w:wars2|WARS2]]|0.41|
|[[:human genes:n:ndufs5|NDUFS5]]|0.41|
|[[:human genes:r:rexo2|REXO2]]|0.407|
|[[:human genes:t:tfb1m|TFB1M]]|0.405|
|[[:human genes:l:lars2|LARS2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|1/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1882
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSFM Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>