TSPY2 [The Human Chemical-Genetic Interaction Map Project]

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======= TSPY2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSPY2
  * **<color #00a2e8>Official Name</color>**: testis specific protein Y-linked 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64591|64591]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NKD2|A6NKD2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSPY2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSPY2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Unknown. May be involved in sperm differentiation and proliferation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gonadal mesoderm development|
|nucleosome assembly|
|mesoderm development|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein-DNA complex assembly|
|gonad development|
|development of primary sexual characteristics|
|mesenchyme development|
|protein-DNA complex subunit organization|
|sex differentiation|
|DNA conformation change|
|reproductive structure development|
|reproductive system development|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|chromatin organization|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|multi-organism reproductive process|
|chromosome organization|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|tissue development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.21|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.21|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.03|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.88|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.87|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.86|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.79|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.76|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.76|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.71|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.7|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.7|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.89|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.98|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.34|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl35|RPL35]]|0.51|
|[[:human genes:p:polr2j3|POLR2J3]]|0.49|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.48|
|[[:human genes:p:prim1|PRIM1]]|0.476|
|[[:human genes:p:psmb4|PSMB4]]|0.475|
|[[:human genes:c:cactin|CACTIN]]|0.475|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.474|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.467|
|[[:human genes:c:chd4|CHD4]]|0.463|
|[[:human genes:p:psma7|PSMA7]]|0.462|
|[[:human genes:n:narfl|NARFL]]|0.461|
|[[:human genes:r:rrp7a|RRP7A]]|0.457|
|[[:human genes:p:psmb2|PSMB2]]|0.457|
|[[:human genes:r:rpl6|RPL6]]|0.453|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.45|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.447|
|[[:human genes:c:chmp4b|CHMP4B]]|0.439|
|[[:human genes:a:ankle1|ANKLE1]]|0.437|
|[[:human genes:p:polr2a|POLR2A]]|0.434|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.434|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.429|
|[[:human genes:d:ddx56|DDX56]]|0.425|
|[[:human genes:r:rps2|RPS2]]|0.421|
|[[:human genes:i:ints5|INTS5]]|0.421|
|[[:human genes:e:exosc8|EXOSC8]]|0.42|
|[[:human genes:t:timeless|TIMELESS]]|0.42|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.419|
|[[:human genes:p:psmb3|PSMB3]]|0.419|
|[[:human genes:r:rpl17|RPL17]]|0.418|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.418|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.417|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.417|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.417|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.417|
|[[:human genes:p:psmd2|PSMD2]]|0.413|
|[[:human genes:f:fgf13|FGF13]]|0.412|
|[[:human genes:o:orc6|ORC6]]|0.41|
|[[:human genes:d:dhx38|DHX38]]|0.408|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.408|
|[[:human genes:p:psma6|PSMA6]]|0.407|
|[[:human genes:p:polr1a|POLR1A]]|0.407|
|[[:human genes:a:aatf|AATF]]|0.407|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.406|
|[[:human genes:x:xab2|XAB2]]|0.404|
|[[:human genes:d:dimt1|DIMT1]]|0.403|
|[[:human genes:m:mastl|MASTL]]|0.403|
|[[:human genes:r:rpl9|RPL9]]|0.402|
|[[:human genes:n:nol10|NOL10]]|0.402|
|[[:human genes:c:copb1|COPB1]]|0.402|
|[[:human genes:e:exosc9|EXOSC9]]|0.401|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.4|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.4|
|[[:human genes:t:tceb3c|TCEB3C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2086
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSPY2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>