TSPY8 [The Human Chemical-Genetic Interaction Map Project]

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======= TSPY8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSPY8
  * **<color #00a2e8>Official Name</color>**: testis specific protein Y-linked 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=728403|728403]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0CW00|P0CW00]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSPY8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSPY8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in sperm differentiation and proliferation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gonadal mesoderm development|
|nucleosome assembly|
|mesoderm development|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein-DNA complex assembly|
|gonad development|
|development of primary sexual characteristics|
|mesenchyme development|
|protein-DNA complex subunit organization|
|sex differentiation|
|DNA conformation change|
|reproductive structure development|
|reproductive system development|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|chromatin organization|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|multi-organism reproductive process|
|chromosome organization|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|tissue development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.03|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.97|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.77|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.73|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.7|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.72|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.76|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.77|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.78|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.81|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.86|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.88|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.96|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.07|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.08|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.26|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.633|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.545|
|[[:human genes:r:rps12|RPS12]]|0.53|
|[[:human genes:c:cdc45|CDC45]]|0.528|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.522|
|[[:human genes:t:tceb3c|TCEB3C]]|0.519|
|[[:human genes:t:tfip11|TFIP11]]|0.511|
|[[:human genes:p:psmb4|PSMB4]]|0.509|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.508|
|[[:human genes:i:ik|IK]]|0.504|
|[[:human genes:n:nupl1|NUPL1]]|0.498|
|[[:human genes:c:ccna2|CCNA2]]|0.495|
|[[:human genes:s:snip1|SNIP1]]|0.486|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.482|
|[[:human genes:m:mt1e|MT1E]]|0.481|
|[[:human genes:a:ankle1|ANKLE1]]|0.481|
|[[:human genes:c:chd4|CHD4]]|0.478|
|[[:human genes:p:psma6|PSMA6]]|0.475|
|[[:human genes:a:aatf|AATF]]|0.475|
|[[:human genes:b:bysl|BYSL]]|0.473|
|[[:human genes:l:lrr1|LRR1]]|0.473|
|[[:human genes:n:nsf|NSF]]|0.473|
|[[:human genes:n:npipb5|NPIPB5]]|0.472|
|[[:human genes:s:supt5h|SUPT5H]]|0.469|
|[[:human genes:r:rrp7a|RRP7A]]|0.467|
|[[:human genes:r:rpl35|RPL35]]|0.467|
|[[:human genes:c:cbwd5|CBWD5]]|0.464|
|[[:human genes:k:kctd17|KCTD17]]|0.463|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.462|
|[[:human genes:s:slc6a17|SLC6A17]]|0.46|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.457|
|[[:human genes:c:cep192|CEP192]]|0.457|
|[[:human genes:s:slc4a1|SLC4A1]]|0.455|
|[[:human genes:s:supt6h|SUPT6H]]|0.453|
|[[:human genes:r:rps2|RPS2]]|0.451|
|[[:human genes:p:pcf11|PCF11]]|0.451|
|[[:human genes:t:twistnb|TWISTNB]]|0.451|
|[[:human genes:v:vps28|VPS28]]|0.45|
|[[:human genes:a:aamp|AAMP]]|0.448|
|[[:human genes:m:mbtd1|MBTD1]]|0.448|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.448|
|[[:human genes:e:exosc9|EXOSC9]]|0.447|
|[[:human genes:c:cdca3|CDCA3]]|0.446|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.446|
|[[:human genes:r:rrn3|RRN3]]|0.446|
|[[:human genes:g:golga8j|GOLGA8J]]|0.445|
|[[:human genes:o:orc6|ORC6]]|0.444|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.444|
|[[:human genes:r:rps3a|RPS3A]]|0.443|
|[[:human genes:o:orc1|ORC1]]|0.443|
|[[:human genes:h:hap1|HAP1]]|0.442|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.441|
|[[:human genes:r:rbbp5|RBBP5]]|0.44|
|[[:human genes:u:upf1|UPF1]]|0.44|
|[[:human genes:c:copg1|COPG1]]|0.44|
|[[:human genes:c:cbwd3|CBWD3]]|0.439|
|[[:human genes:n:nfatc4|NFATC4]]|0.439|
|[[:human genes:s:s1pr4|S1PR4]]|0.439|
|[[:human genes:a:acsf2|ACSF2]]|0.438|
|[[:human genes:p:pola1|POLA1]]|0.436|
|[[:human genes:z:znf655|ZNF655]]|0.436|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.435|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.435|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.434|
|[[:human genes:d:dock6|DOCK6]]|0.434|
|[[:human genes:e:exosc4|EXOSC4]]|0.433|
|[[:human genes:r:rpl34|RPL34]]|0.432|
|[[:human genes:l:loc643669|LOC643669]]|0.432|
|[[:human genes:o:or10g3|OR10G3]]|0.432|
|[[:human genes:i:igfn1|IGFN1]]|0.431|
|[[:human genes:p:pole|POLE]]|0.431|
|[[:human genes:r:rrp15|RRP15]]|0.431|
|[[:human genes:c:cactin|CACTIN]]|0.431|
|[[:human genes:r:rpl8|RPL8]]|0.43|
|[[:human genes:s:smtn|SMTN]]|0.428|
|[[:human genes:n:nup43|NUP43]]|0.426|
|[[:human genes:c:cdc6|CDC6]]|0.425|
|[[:human genes:n:narfl|NARFL]]|0.424|
|[[:human genes:t:terf1|TERF1]]|0.424|
|[[:human genes:p:polr2j|POLR2J]]|0.423|
|[[:human genes:p:plk4|PLK4]]|0.423|
|[[:human genes:g:gosr2|GOSR2]]|0.423|
|[[:human genes:u:ubap1|UBAP1]]|0.422|
|[[:human genes:r:rad51|RAD51]]|0.422|
|[[:human genes:r:rpl9|RPL9]]|0.422|
|[[:human genes:n:nop16|NOP16]]|0.422|
|[[:human genes:d:dtl|DTL]]|0.421|
|[[:human genes:w:wdr75|WDR75]]|0.421|
|[[:human genes:k:krt78|KRT78]]|0.421|
|[[:human genes:p:plekha4|PLEKHA4]]|0.42|
|[[:human genes:t:tsg101|TSG101]]|0.42|
|[[:human genes:f:fam25b|FAM25B]]|0.42|
|[[:human genes:p:psmd3|PSMD3]]|0.42|
|[[:human genes:r:rps19|RPS19]]|0.419|
|[[:human genes:t:ticrr|TICRR]]|0.418|
|[[:human genes:m:madcam1|MADCAM1]]|0.418|
|[[:human genes:c:cbwd6|CBWD6]]|0.418|
|[[:human genes:r:ranbp2|RANBP2]]|0.417|
|[[:human genes:n:nup93|NUP93]]|0.417|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.417|
|[[:human genes:c:chmp4b|CHMP4B]]|0.416|
|[[:human genes:r:rpl6|RPL6]]|0.416|
|[[:human genes:t:ttk|TTK]]|0.416|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.414|
|[[:human genes:t:timeless|TIMELESS]]|0.413|
|[[:human genes:p:psmd1|PSMD1]]|0.413|
|[[:human genes:z:znf830|ZNF830]]|0.412|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.412|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.412|
|[[:human genes:d:disp2|DISP2]]|0.412|
|[[:human genes:d:ddtl|DDTL]]|0.412|
|[[:human genes:x:xylt2|XYLT2]]|0.412|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.411|
|[[:human genes:s:sf3a1|SF3A1]]|0.411|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.411|
|[[:human genes:c:c14orf93|C14orf93]]|0.411|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.411|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.411|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.41|
|[[:human genes:a:akirin2|AKIRIN2]]|0.41|
|[[:human genes:s:stil|STIL]]|0.409|
|[[:human genes:g:gga3|GGA3]]|0.409|
|[[:human genes:a:acd|ACD]]|0.409|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.408|
|[[:human genes:n:napa|NAPA]]|0.408|
|[[:human genes:n:nol10|NOL10]]|0.406|
|[[:human genes:i:ints6|INTS6]]|0.406|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.405|
|[[:human genes:e:exd1|EXD1]]|0.404|
|[[:human genes:d:ddx56|DDX56]]|0.404|
|[[:human genes:s:slc38a7|SLC38A7]]|0.404|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.404|
|[[:human genes:m:mepce|MEPCE]]|0.403|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.403|
|[[:human genes:u:uqcrh|UQCRH]]|0.403|
|[[:human genes:p:polr2j2|POLR2J2]]|0.403|
|[[:human genes:c:cdt1|CDT1]]|0.403|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.402|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.402|
|[[:human genes:c:ccdc94|CCDC94]]|0.402|
|[[:human genes:t:taf1|TAF1]]|0.401|
|[[:human genes:a:arcn1|ARCN1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1968
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSPY8 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>